BC 11 hydrobromide

Pricing Availability   Qty
Cat.No. 4372 - BC 11 hydrobromide | C8H11BN2O2S.HBr | CAS No. 443776-49-6
Description: Selective urokinase (uPA) inhibitor
Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Compound Libraries

BC 11 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 290.97
Formula C8H11BN2O2S.HBr
Storage Store at -20°C
CAS Number 443776-49-6
PubChem ID 78243712
InChI Key PAFZAMOVHIRQOD-UHFFFAOYSA-N
Smiles NC(SCC1=CC=C(B(O)O)C=C1)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.1 100
water 5.82 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 290.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.18 mL 34.37 mL
5 mM 0.69 mL 3.44 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819

Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857


If you know of a relevant reference for BC 11 hydrobromide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Urokinase Inhibitors

Keywords: BC 11 hydrobromide, BC 11 hydrobromide supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, 4372, Tocris Bioscience

3 Citations for BC 11 hydrobromide

Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114

Semina et al (2016) Urokinase and urok. receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124

Magnussen et al (2017) Cleavage of the urok. receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer 17 350 PMID: 28526008


Do you know of a great paper that uses BC 11 hydrobromide from Tocris? Please let us know.

Reviews for BC 11 hydrobromide

There are currently no reviews for this product. Be the first to review BC 11 hydrobromide and earn rewards!

Have you used BC 11 hydrobromide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure