BC 11 hydrobromide
Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||5.82||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.44 mL||17.18 mL||34.37 mL|
|5 mM||0.69 mL||3.44 mL||6.87 mL|
|10 mM||0.34 mL||1.72 mL||3.44 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857
If you know of a relevant reference for BC 11 hydrobromide, please let us know.
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Keywords: BC 11 hydrobromide, supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, Tocris Bioscience
1 Citation for BC 11 hydrobromide
Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:
Semina et al (2016) Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124
Do you know of a great paper that uses BC 11 hydrobromide from Tocris? If so please let us know.