BC 11 hydrobromide

Pricing Availability   Qty
Description: Selective urokinase (uPA) inhibitor
Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Datasheet
Citations (3)
Reviews (1)

Biological Activity for BC 11 hydrobromide

BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Technical Data for BC 11 hydrobromide

M. Wt 290.97
Formula C8H11BN2O2S.HBr
Storage Store at -20°C
CAS Number 443776-49-6
PubChem ID 78243712
InChI Key PAFZAMOVHIRQOD-UHFFFAOYSA-N
Smiles NC(SCC1=CC=C(B(O)O)C=C1)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BC 11 hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.1 100
water 5.82 20 with gentle warming

Preparing Stock Solutions for BC 11 hydrobromide

The following data is based on the product molecular weight 290.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.18 mL 34.37 mL
5 mM 0.69 mL 3.44 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets for BC 11 hydrobromide

References for BC 11 hydrobromide

References are publications that support the biological activity of the product.

Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819

Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857


If you know of a relevant reference for BC 11 hydrobromide, please let us know.

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Keywords: BC 11 hydrobromide, BC 11 hydrobromide supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, 4372, Tocris Bioscience

3 Citations for BC 11 hydrobromide

Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

Magnussen et al (2017) Cleavage of the urok. receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer 17 350 PMID: 28526008

Semina et al (2016) Urokinase and urok. receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124

Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114


Do you know of a great paper that uses BC 11 hydrobromide from Tocris? Please let us know.

Reviews for BC 11 hydrobromide

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Cell cultures with ECM proteins, integrin blockade and In vitro drug treatments.
By Anonymous on 03/24/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat astroglioma C6 cells

20 µM

PMID: 29222114
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