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BC 11 hydrobromide
Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||5.82||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.44 mL||17.18 mL||34.37 mL|
|5 mM||0.69 mL||3.44 mL||6.87 mL|
|10 mM||0.34 mL||1.72 mL||3.44 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References are publications that support the biological activity of the product.
Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819
Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857
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Keywords: BC 11 hydrobromide, BC 11 hydrobromide supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, 4372, Tocris Bioscience
3 Citations for BC 11 hydrobromide
Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:
Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114
Semina et al (2016) Urokinase and urok. receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124
Magnussen et al (2017) Cleavage of the urok. receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer 17 350 PMID: 28526008
Do you know of a great paper that uses BC 11 hydrobromide from Tocris? Please let us know.
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