BC 11 hydrobromide

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Cat.No. 4372 - BC 11 hydrobromide | C8H11BN2O2S.HBr | CAS No. 443776-49-6
Description: Selective urokinase (uPA) inhibitor
Chemical Name: Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
Datasheet
Citations (1)
Literature

Biological Activity

Selective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

Compound Libraries

BC 11 hydrobromide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 290.97
Formula C8H11BN2O2S.HBr
Storage Store at -20°C
CAS Number 443776-49-6
PubChem ID 78243712
InChI Key PAFZAMOVHIRQOD-UHFFFAOYSA-N
Smiles NC(SCC1=CC=C(B(O)O)C=C1)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.1 100
water 5.82 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 290.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.18 mL 34.37 mL
5 mM 0.69 mL 3.44 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819 PMID:

Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857


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Keywords: BC 11 hydrobromide, supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, Tocris Bioscience

1 Citation for BC 11 hydrobromide

Citations are publications that use Tocris products. Selected citations for BC 11 hydrobromide include:

Semina et al (2016) Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124


Do you know of a great paper that uses BC 11 hydrobromide from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pathways for BC 11 hydrobromide

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