Non-selective HDACs

There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is divided into classes I, II and IV. Below are a selection of compounds that target two or more classes of HDACs.

Products
Background
Literature

Inhibitors

Cat No Product Name / Activity
4846 Apicidin
Potent histone deacetylase inhibitor
6249 Givinostat hydrochloride
Histone deacetylase inhibitor
2771 M 344
Histone deacetylase inhibitor
3747 NCH 51
Histone deacetylase inhibitor
2521 NSC 3852
Histone deacetylase inhibitor
2682 Sodium 4-Phenylbutyrate
Histone deacetylase inhibitor
4652 SAHA
Class I and II HDAC inhibitor
2421 Scriptaid
Histone deacetylase inhibitor
3850 Sodium butyrate
Histone deacetylase inhibitor
1406 Trichostatin A
Potent histone deacetylase inhibitor
2815 Valproic acid, sodium salt
Histone deacetylase inhibitor

HDAC classification

Superfamily Family Class Subclass Protein (human)
Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
ClassIIb HDAC6, HDAC10
Class IV HDAC11
Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3
II SIRT4
III SIRT5
IV SIRT6, SIRT7

Literature for Non-selective HDACs

Tocris offers the following scientific literature for Non-selective HDACs to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.