Sodium butyrate

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Cat.No. 3850 - Sodium butyrate | C4H7NaO2 | CAS No. 156-54-7
Description: Histone deacetylase inhibitor
Chemical Name: Butanoic acid sodium salt

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Also augments transcription factor stimulated iPSC generation.

Technical Data

M. Wt 110.09
Formula C4H7NaO2
Storage Store at RT
CAS Number 156-54-7
PubChem ID 5222465
Smiles [Na+].CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 11.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 110.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.08 mL 45.42 mL 90.83 mL
5 mM 1.82 mL 9.08 mL 18.17 mL
10 mM 0.91 mL 4.54 mL 9.08 mL
50 mM 0.18 mL 0.91 mL 1.82 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576

Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553

Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386

Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312

Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530

If you know of a relevant reference for Sodium butyrate, please let us know.

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