Sodium butyrate

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Cat.No. 3850 - Sodium butyrate | C4H7NaO2 | CAS No. 156-54-7
Description: Histone deacetylase inhibitor
Chemical Name: Butanoic acid sodium salt
Datasheet
Citations
Reviews
Literature

Biological Activity

Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Also augments transcription factor stimulated iPSC generation.

Technical Data

M. Wt 110.09
Formula C4H7NaO2
Storage Store at RT
CAS Number 156-54-7
PubChem ID 5222465
InChI Key MFBOGIVSZKQAPD-UHFFFAOYSA-M
Smiles [Na+].CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 11.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 110.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.08 mL 45.42 mL 90.83 mL
5 mM 1.82 mL 9.08 mL 18.17 mL
10 mM 0.91 mL 4.54 mL 9.08 mL
50 mM 0.18 mL 0.91 mL 1.82 mL

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References

References are publications that support the biological activity of the product.

Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576

Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553

Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386

Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312

Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530


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Keywords: Sodium butyrate, Sodium butyrate supplier, Histone, deacetylase, inhibitors, inhibits, differentiation, progenitors, ESC, HDACs, stem, cells, epigenetics, Hepatocyte, Stem, Cells, Non-selective, Non-Selective, 3850, Tocris Bioscience

Citations for Sodium butyrate

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Rheumatoid Arthritis

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.