Histone deacetylase inhibitor. Restores contextual memory in a transgenic mouse model of Alzheimer's disease. Shown to induce pancreatic progenitor formation. Directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Also augments transcription factor stimulated iPSC generation.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 110.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.08 mL||45.42 mL||90.83 mL|
|5 mM||1.82 mL||9.08 mL||18.17 mL|
|10 mM||0.91 mL||4.54 mL||9.08 mL|
|50 mM||0.18 mL||0.91 mL||1.82 mL|
References are publications that support the products' biological activity.
Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576
Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553
Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386
Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312
Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530
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Keywords: Sodium butyrate, supplier, Histone, deacetylase, inhibitors, inhibits, differentiation, progenitors, ESC, HDACs, stem, cells, epigenetics, Histone, Deacetylases, Hepatocyte, Stem, Cells, Histone, Deacetylases, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.