Sodium butyrate

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Description: Histone deacetylase inhibitor
Chemical Name: Butanoic acid sodium salt
Reviews (1)
Literature (2)

Biological Activity for Sodium butyrate

Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.

Technical Data for Sodium butyrate

M. Wt 110.09
Formula C4H7NaO2
Storage Store at RT
CAS Number 156-54-7
PubChem ID 5222465
Smiles [Na+].CCCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sodium butyrate

Solvent Max Conc. mg/mL Max Conc. mM
water 11.01 100

Preparing Stock Solutions for Sodium butyrate

The following data is based on the product molecular weight 110.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 9.08 mL 45.42 mL 90.83 mL
5 mM 1.82 mL 9.08 mL 18.17 mL
10 mM 0.91 mL 4.54 mL 9.08 mL
50 mM 0.18 mL 0.91 mL 1.82 mL

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Product Datasheets for Sodium butyrate

References for Sodium butyrate

References are publications that support the biological activity of the product.

Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576

Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553

Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386

Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312

Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530

Ferrante et al (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J.Neurosci. 23 9418 PMID: 14561870

Yu et al (2022) Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J.Cell.Mol.Med. 26 3031 PMID: 35429101

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View Related Products by Product Action

View all Non-selective Histone Deacetylase Inhibitors

Keywords: Sodium butyrate, Sodium butyrate supplier, Histone, deacetylase, inhibitors, inhibits, differentiation, progenitors, ESC, HDACs, stem, cells, epigenetics, Huntingtons, Alzheimers, neurodegeneration, Hepatocyte, Stem, Cells, Non-selective, Non-Selective, 3850, Tocris Bioscience

Citations for Sodium butyrate

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Reviews for Sodium butyrate

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Acetylation assay.
By Xiaoyu Zhang on 03/07/2024
Assay Type: In Vitro
Species: Human

5mM sodium butyrate added to in vitro acetylation assay buffer.Western Blot to detect histone acetylation. Lane1 is control. Lane 2 is treatment. It showed acetylation unregulated after treatment.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.