Givinostat hydrochloride

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Cat.No. 6249 - Givinostat hydrochloride | C24H27N3O4.HCl | CAS No. 199657-29-9
Description: Histone deacetylase inhibitor
Chemical Name: [6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.

Technical Data

M. Wt 457.95
Formula C24H27N3O4.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 199657-29-9
PubChem ID 10095659
Smiles CCN(CC1=CC2=C(C=C(C=C2)COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C1)CC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.8 100

Preparing Stock Solutions

The following data is based on the product molecular weight 457.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.92 mL 21.84 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References are publications that support the products' biological activity.

Leoni et al (2005) The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol.Med. 11 1 PMID: 16557334

Shein et al (2009) Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB.J. 23 4266 PMID: 19723705

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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