Class I HDACs

Class I (Rpd3-like) proteins comprise HDAC1, HDAC2, HDAC3, and HDAC8 and are predominantly expressed in the nucleus.

Literature (5)
Gene Data

Class I HDAC Inhibitors

Cat. No. Product Name / Activity
6284 BRD 73954
Dual histone deacetylase (HDAC) 6/8 inhibitor
2952 CI 994
Class I histone deacetylase inhibitor; orally active
3515 FK 228
Potent and selective class I histone deacetylase inhibitor; antitumor
5727 MC 1742
Potent class I and IIb HDAC inhibitor
6208 MS 275
HDAC (Class I) inhibitor
4902 NSC 405020
Histone deacetylase inhibitor
4643 PCI 34051
Potent and selective HDAC8 inhibitor
4403 Pyroxamide
Histone deacetylase inhibitor
6728 RGFP 966
Potent and selective HDAC3 inhibitor
7191 Santacruzamate A
Highly potent and selective HDAC2 inhibitor
3810 SBHA
HDAC1/3 inhibitor
4270 TC-H 106
Class I histone deacetylase inhibitor

HDAC classification

Superfamily Family Class Subclass Protein (human)
Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
ClassIIb HDAC6, HDAC10
Class IV HDAC11
Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3

External sources of pharmacological information for Class I HDACs :

    Literature for Class I HDACs

    Tocris offers the following scientific literature for Class I HDACs to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis

    Epigenetics Scientific Review

    Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

    Cell Cycle & DNA Damage Repair

    Cell Cycle & DNA Damage Repair Poster

    In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

    Epigenetics in Cancer

    Epigenetics in Cancer Poster

    Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

    Rheumatoid Arthritis

    Rheumatoid Arthritis Poster

    Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.

    Histone Deacetylase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Class 1
    HDAC1 Human HDAC1 NM_004964 Q13547
    Mouse Hdac1 NM_008228 O09106
    Rat Hdac1 NM_001025409 Q4QQW4
    HDAC2 Human HDAC2 NM_001527 Q92769
    Mouse Hdac2 NM_008229 P70288
    Rat Hdac2 NM_053447 Q99PA1
    HDAC3 Human HDAC3 NM_003883 O15379
    Mouse Hdac3 NM_010411 O88895
    Rat Hdac3 NM_053448 Q6P6W3
    HDAC8 Human HDAC8 NM_018486 Q9BY41
    Mouse Hdac8 NM_027382 Q8VH37
    Rat Hdac8 NM_001126373 XP_343805
    Class 2
    HDAC4 Human HDAC4 NM_006037 P56524
    Mouse Hdac4 NM_207225 Q6NZM9
    Rat Hdac4 XM_343629 Q99P99
    HDAC5 Human HDAC5 NM_001015053 Q9UQL6
    Mouse Hdac5 NM_001077696 Q9Z2V6
    Rat Hdac5 XM_001081495 Q5RJZ2
    HDAC6 Human HDAC6 NM_006044 Q9UBN7
    Mouse Hdac6 NM_010413 Q9Z2V5
    Rat Hdac6 XM_228753 Q99P97
    HDAC7 Human HDAC7 NM_016596 Q9UFU7
    Mouse Hdac7 NM_019572 Q8C2B3
    Rat Hdac7a XM_345868 Q99P96
    HDAC9 Human HDAC9 NM_058177 Q9UKV0
    Mouse Hdac9 NM_024124 Q99N13
    HDAC10 Human HDAC10 NM_032019 Q969S8
    Mouse Hdac10 NM_199198 Q6P3E7
    Rat Hdac10 NM_001035000 Q569C4
    Class 4
    HDAC11 Human HDAC11 NM_024827 Q96DB2
    Mouse Hdac11 NM_144919 Q91WA3
    Rat Hdac11 NM_001106610 XP_238362