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Class I HDACs

Class I (Rpd3-like) proteins comprise HDAC1, HDAC2, HDAC3, and HDAC8 and are predominantly expressed in the nucleus.

Products
Background
Literature (4)
Gene Data

Class I HDAC Inhibitors
Cat. No. Product Name / Activity
6284 BRD 73954
Dual histone deacetylase (HDAC) 6/8 inhibitor
8811 ESI 1
Selective HDAC3 inhibitor; also myelination inducer
3515 FK 228
Potent and selective class I histone deacetylase inhibitor; antitumor
5727 MC 1742
Potent class I and IIb HDAC inhibitor
6208 MS 275
HDAC (Class I) inhibitor
4902 NSC 405020
Histone deacetylase inhibitor
4643 PCI 34051
Potent and selective HDAC8 inhibitor
6728 RGFP 966
Potent and selective HDAC3 inhibitor
7191 Santacruzamate A
Highly potent and selective HDAC2 inhibitor

Degraders
Cat. No. Product Name / Activity
8083 JPS016
Selective class I HDAC Degrader (PROTAC®)
8085 JPS036
Selective HDAC3 Degrader (PROTAC®)

Controls
Cat. No. Product Name / Activity
8084 JPS016NC
Negative control for JPS036 (Cat. No. 8085).

Other
Cat. No. Product Name / Activity
7970 SAHA-FITC
Fluorescent HDAC1/2 probe; suitable for use in TR-FRET and FP assays

Related Targets

    HDAC classification

    Superfamily Family Class Subclass Protein (human)
    Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
    Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
    ClassIIb HDAC6, HDAC10
    Class IV HDAC11
    Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3
    II SIRT4
    III SIRT5
    IV SIRT6, SIRT7

    External sources of pharmacological information for Class I HDACs :

      Literature for Class I HDACs

      Tocris offers the following scientific literature for Class I HDACs to showcase our products. We invite you to request* your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.

      Epigenetics Scientific Review

      Epigenetics Scientific Review

      Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

      Cell Cycle & DNA Damage Repair Poster

      Cell Cycle & DNA Damage Repair Poster

      In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

      Epigenetics in Cancer Poster

      Epigenetics in Cancer Poster

      This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

      Rheumatoid Arthritis Poster

      Rheumatoid Arthritis Poster

      Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.

      Histone Deacetylase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      Class 1
      HDAC1 Human HDAC1 NM_004964 Q13547
      Mouse Hdac1 NM_008228 O09106
      Rat Hdac1 NM_001025409 Q4QQW4
      HDAC2 Human HDAC2 NM_001527 Q92769
      Mouse Hdac2 NM_008229 P70288
      Rat Hdac2 NM_053447 Q99PA1
      HDAC3 Human HDAC3 NM_003883 O15379
      Mouse Hdac3 NM_010411 O88895
      Rat Hdac3 NM_053448 Q6P6W3
      HDAC8 Human HDAC8 NM_018486 Q9BY41
      Mouse Hdac8 NM_027382 Q8VH37
      Rat Hdac8 NM_001126373 XP_343805
      Class 2
      HDAC4 Human HDAC4 NM_006037 P56524
      Mouse Hdac4 NM_207225 Q6NZM9
      Rat Hdac4 XM_343629 Q99P99
      HDAC5 Human HDAC5 NM_001015053 Q9UQL6
      Mouse Hdac5 NM_001077696 Q9Z2V6
      Rat Hdac5 XM_001081495 Q5RJZ2
      HDAC6 Human HDAC6 NM_006044 Q9UBN7
      Mouse Hdac6 NM_010413 Q9Z2V5
      Rat Hdac6 XM_228753 Q99P97
      HDAC7 Human HDAC7 NM_016596 Q9UFU7
      Mouse Hdac7 NM_019572 Q8C2B3
      Rat Hdac7a XM_345868 Q99P96
      HDAC9 Human HDAC9 NM_058177 Q9UKV0
      Mouse Hdac9 NM_024124 Q99N13
      HDAC10 Human HDAC10 NM_032019 Q969S8
      Mouse Hdac10 NM_199198 Q6P3E7
      Rat Hdac10 NM_001035000 Q569C4
      Class 4
      HDAC11 Human HDAC11 NM_024827 Q96DB2
      Mouse Hdac11 NM_144919 Q91WA3
      Rat Hdac11 NM_001106610 XP_238362