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Histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.
Sodium 4-Phenylbutyrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 186.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.37 mL||26.86 mL||53.71 mL|
|5 mM||1.07 mL||5.37 mL||10.74 mL|
|10 mM||0.54 mL||2.69 mL||5.37 mL|
|50 mM||0.11 mL||0.54 mL||1.07 mL|
References are publications that support the biological activity of the product.
Appelskog et al (2004) Histone deacetylase inhibitor 4-phenylbutyrate suppresses GADPH mRNA expression in glioma cells. Int.J.Oncol. 24 1419 PMID: 15138583
Ammerpohl et al (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br.J.Cancer 96 73 PMID: 17164759
Engelhard et al (1998) Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. J.Neuro-Oncol. 37 97
Khan et al (2011) HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int.J.Mol.Med. 28 977 PMID: 21894430
If you know of a relevant reference for Sodium 4-Phenylbutyrate, please let us know.
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Keywords: Sodium 4-Phenylbutyrate, Sodium 4-Phenylbutyrate supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, epigenetics, 4-PB, Sodium, phenylbutyrate, Non-selective, HDACs, Non-Selective, 2682, Tocris Bioscience
2 Citations for Sodium 4-Phenylbutyrate
Citations are publications that use Tocris products. Selected citations for Sodium 4-Phenylbutyrate include:
Myszor et al (2019) Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity. Sci Rep 9 7114 PMID: 31068616
Karadottir et al (2015) Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells. Oncotarget 3 e1483 PMID: 26664810
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.