Natriuretic Peptide Receptors

Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1912 Atrial natriuretic factor (1-28) (rat)
Endogenous peptide regulating blood pressure
1906 Atrial natriuretic factor (1-28) (human, porcine)
Endogenous peptide regulating blood pressure
3522 Brain natriuretic peptide (1-32) (human)
Endogenous peptide agonist at ANP receptor A (NPR1)
3520 C-type natriuretic peptide (1-22) (human, rat, swine)
Endogenous peptide agonist at NPR2

Antagonists

Cat No Product Name / Activity
5498 AP 811
High affinity, selective NPR3 antagonist

Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.

Natriuretic peptide receptors bind α-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is the homeostasis of body fluid volume.

External sources of pharmacological information for Natriuretic Peptide Receptors :

    Literature for Natriuretic Peptide Receptors

    Cardiovascular

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    Natriuretic Peptide Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    NPR1 Human NPR1 NM_000906 P16066
    Mouse Npr1 NM_008727 P18293
    Rat Npr1 NM_012613 P18910
    NPR2 Human NPR2 NM_003995 P20594
    Mouse Npr2 NM_173788 Q6VVW5
    Rat Npr2 NM_053838 P16067
    NPR3 Human NPR3 NM_000908 P17342
    Mouse Npr3 NM_008728 P70180
    Rat Npr3 NM_012868 P41740