Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.
Natriuretic Peptide Receptor Agonists |
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Cat. No. | Product Name / Activity |
1912 | Atrial natriuretic factor (1-28) (rat) |
Endogenous peptide regulating blood pressure | |
1906 | Atrial natriuretic factor (1-28) (human, porcine) |
Endogenous peptide regulating blood pressure | |
3522 | Brain natriuretic peptide (1-32) (human) |
Endogenous peptide agonist at ANP receptor A (NPR1) | |
3520 | C-type natriuretic peptide (1-22) (human, rat, swine) |
Endogenous peptide agonist at NPR2 | |
Natriuretic Peptide Receptor Antagonists |
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Cat. No. | Product Name / Activity |
6715 | A 71915 |
Highly potent and competitive NPRA antagonist | |
5498 | AP 811 |
High affinity, selective NPR3 antagonist |
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.
Natriuretic peptide receptors bind α-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is the homeostasis of body fluid volume.
Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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NPR1 | Human | NPR1 | NM_000906 | P16066 |
Mouse | Npr1 | NM_008727 | P18293 | |
Rat | Npr1 | NM_012613 | P18910 | |
NPR2 | Human | NPR2 | NM_003995 | P20594 |
Mouse | Npr2 | NM_173788 | Q6VVW5 | |
Rat | Npr2 | NM_053838 | P16067 | |
NPR3 | Human | NPR3 | NM_000908 | P17342 |
Mouse | Npr3 | NM_008728 | P70180 | |
Rat | Npr3 | NM_012868 | P41740 |