Atrial natriuretic factor (1-28) (rat)

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Cat.No. 1912 - Atrial Natriuretic Factor (1-28) (rat) | Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: 7 - 23) | CAS No. 88898-17-3
Description: Endogenous peptide regulating blood pressure
Alternative Names: Atrial Natriuretic Peptide (1-28) (rat)
Datasheet
Citations

Biological Activity

Endogenous peptide produced by the heart; involved in blood pressure regulation. Produces natriuresis, diuresis and vasorelaxation in vivo.

Technical Data

M. Wt 3062.43
Formula C128H205N45O39S2
Sequence SLRRSSCFGGRIDRIGAQSGLGCNSFRY

(Modifications: Disulfide bridge between 7 - 23)

Storage Desiccate at -20°C
CAS Number 88898-17-3
PubChem ID 16166338
InChI Key QGFSVPWZEPKNDV-BRTFOEFASA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3062.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.63 mL 3.27 mL
5 mM 0.07 mL 0.33 mL 0.65 mL
10 mM 0.03 mL 0.16 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Atlas et al (1985) Atrial natriuretic factor (auriculin): structure and biological effects. J.Clin.Hypertens. 1 187 PMID: 2941526

de Bold et al (1985) Atrial natriuretic factor: a hormone produced by the heart. Science 230 767 PMID: 2932797

Rubattu and Volpe (2001) The atrial natriuretic peptide: a changing view. J.Hypertens. 19 1923 PMID: 11677356


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Keywords: Endogenous peptide regulating blood pressure ANP Receptors Atrial Natriuretic Peptide NPR Atrial Natriuretic Peptide (1-28) (rat) Natriuretic Peptide Receptor Peptide

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