AP 811

Pricing Availability   Qty
Cat.No. 5498 - AP 811 | N2-[4-(2-Naphthoylamino)phenylacetyl]-Arg-Ile-Asp-Arg-(S)-2-methylbutylamide | CAS No. 124833-45-0
Description: High affinity, selective NPR3 antagonist
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Technical Data

M. Wt 915.1
Formula C46H66N12O8
Sequence RIDR

(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

Storage Store at -20°C
CAS Number 124833-45-0
PubChem ID 44301714
InChI Key UNMJSSQZDQBGDS-OCFLPWLCSA-N
Smiles CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Veale et al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949 PMID: 10987424

William et al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067 PMID: 18272821

Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID: 24353062


If you know of a relevant reference for AP 811, please let us know.

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Keywords: AP 811, AP 811 supplier, AP811, NPR3, ANP-CR, atrial, natriuretic, peptides, clearance, receptor, antagonists, antagonism, selective, high, affinity, Natriuretic, Peptide, Receptor, 5498, Tocris Bioscience

Citations for AP 811

Citations are publications that use Tocris products.

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Reviews for AP 811

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Good NPR3 agonist
By Anonymous on 07/12/2018
Assay Type: Ex Vivo
Species: Rat

Investigation of NPR3 agonism in blood vessels.

AP811 is extremely unstable. Shipped at RT as powder, but need to be frozen upon arrival and made fresh each time.


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Cardiovascular

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