AP 811

Pricing Availability Delivery Time Qty
Cat.No. 5498 - AP 811 | N2-[4-(2-Naphthoylamino)phenylacetyl]-Arg-Ile-Asp-Arg-(S)-2-methylbutylamide | CAS No. 124833-45-0
Description: High affinity, selective NPR3 antagonist
Datasheet
Citations
Literature

Biological Activity

High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Technical Data

M. Wt 915.1
Formula C46H66N12O8
Sequence RIDR

(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

Storage Store at -20°C
CAS Number 124833-45-0
PubChem ID 44301714
InChI Key UNMJSSQZDQBGDS-OCFLPWLCSA-N
Smiles CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1=CC=C(NC(=O)C2=CC3=C(C=CC=C3)C=C2)C=C1)[C@@H](C)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 915.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.46 mL 10.93 mL
5 mM 0.22 mL 1.09 mL 2.19 mL
10 mM 0.11 mL 0.55 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Veale et al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949 PMID: 10987424

William et al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067 PMID: 18272821

Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID: 24353062


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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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