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Biological Activity for A 71915
A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.
Technical Data for A 71915
(Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge: 2-13)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for A 71915
|Solubility||Soluble to 1 mg/ml in water|
References for A 71915
References are publications that support the biological activity of the product.
Delporte et al (1992) Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 224 183 PMID: 1334838
Moro et al (2004) Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 308 984 PMID: 14634036
Kiguchi et al (2016) Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 356 596 PMID: 26669425
If you know of a relevant reference for A 71915, please let us know.
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Keywords: A 71915, A 71915 supplier, A71915, natriuretic, peptide, receptor, NPRA, NPR1, antagonists, antagonism, potent, competitive, Natriuretic, Peptide, Receptor, 6715, Tocris Bioscience
1 Citation for A 71915
Citations are publications that use Tocris products. Selected citations for A 71915 include:
Hui et al (2022) Atrial Natriuretic Peptide and the Epithelial Sodium Channel Contribute to Spinal Cord Injury-Induced Polyuria in Mice. J Neurotrauma 39 724-734 PMID: 35216518
Do you know of a great paper that uses A 71915 from Tocris? Please let us know.
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