A 71915

Pricing Availability   Qty
Cat.No. 6715 - A 71915 | Arg-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 | CAS No. 132956-87-7
Description: Highly potent and competitive NPRA antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.

Technical Data

M. Wt 1613.95
Formula C69H116N26O15S2
Sequence RCXGGRIDRIXRC

(Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge between Cys-2 - Cys-13)

Storage Store at -20°C
CAS Number 132956-87-7
PubChem ID 25083020
InChI Key TZQXLCWSYQJGKV-YGLLJKSHSA-N
Smiles CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Delporte et al (1992) Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 224 183 PMID: 1334838

Moro et al (2004) Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 308 984 PMID: 14634036

Kiguchi et al (2016) Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 356 596 PMID: 26669425


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Cardiovascular

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