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Submit ReviewC-type natriuretic peptide (1-22) (human, rat, swine)
Description: Endogenous peptide agonist at NPR2
Purity: ≥95% (HPLC)
Biological Activity
C-type natriuretic peptide (1-22) (human, rat, swine) is an endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.
Technical Data
| M. Wt | 2197.61 |
| Formula | C93H157N27O28S3 |
| Sequence |
GLSKGCFGLKLDRIGSMSGLGC (Modifications: Disulfide bridge: 6-22) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 127869-51-6 |
| PubChem ID | 16179407 |
| InChI Key | UHSBKBYWHCBDCJ-DYGWFTAGSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID: 1309330
Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID: 17681481
Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID: 18006579
If you know of a relevant reference for C-type natriuretic peptide (1-22) (human, rat, swine), please let us know.
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Keywords: C-type natriuretic peptide (1-22) (human, rat, swine), C-type natriuretic peptide (1-22) (human, rat, swine) supplier, Endogenous, peptide, agonists, NPR2, ANP, Receptors, Atrial, Natriuretic, Peptide, Receptor, 3520, Tocris Bioscience
1 Citation for C-type natriuretic peptide (1-22) (human, rat, swine)
Citations are publications that use Tocris products. Selected citations for C-type natriuretic peptide (1-22) (human, rat, swine) include:
Stott et al (2015) Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension 65 676 PMID: 25547342
Do you know of a great paper that uses C-type natriuretic peptide (1-22) (human, rat, swine) from Tocris? Please let us know.
Reviews for C-type natriuretic peptide (1-22) (human, rat, swine)
Average Rating: 5 (Based on 1 Review.)
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NP in vitro.
By
Anonymous on 08/05/2018
Assay Type: In Vitro
Species: Human
Used in vitro to investigate different roles of NP family members.
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Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
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- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure