C-type natriuretic peptide (1-22) (human, rat, swine)

Pricing Availability Delivery Time Qty
Cat.No. 3520 - C-type natriuretic peptide (1-22) (human, rat, swine) | Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys | CAS No. 127869-51-6
Description: Endogenous peptide agonist at NPR2
Datasheet
Citations

Biological Activity

Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.

Technical Data

M. Wt 2197.61
Formula C93H157N27O28S3
Sequence GLSKGCFGLKLDRIGSMSGLGC

(Modifications: Disulfide bridge between 6 - 22)

Storage Desiccate at -20°C
CAS Number 127869-51-6
PubChem ID 16179407
InChI Key UHSBKBYWHCBDCJ-DYGWFTAGSA-N
Smiles [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2197.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.46 mL 2.28 mL 4.55 mL
5 mM 0.09 mL 0.46 mL 0.91 mL
10 mM 0.05 mL 0.23 mL 0.46 mL
50 mM 0.01 mL 0.05 mL 0.09 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID: 1309330

Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID: 17681481

Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID: 18006579


If you know of a relevant reference for C-type natriuretic peptide (1-22) (human, rat, swine), please let us know.

View Related Products by Target

Keywords: Endogenous peptide agonists NPR2 ANP Receptors Atrial Natriuretic Peptide Natriuretic Peptide Receptor Peptide

Citations for C-type natriuretic peptide (1-22) (human, rat, swine)

Citations are publications that use Tocris products.

Currently there are no citations for C-type natriuretic peptide (1-22) (human, rat, swine). Do you know of a great paper that uses C-type natriuretic peptide (1-22) (human, rat, swine) from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for C-type natriuretic peptide (1-22) (human, rat, swine)

Protocols

TODO: Add Protocols