C-type natriuretic peptide (1-22) (human, rat, swine)

Pricing Availability   Qty
Description: Endogenous peptide agonist at NPR2
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Reviews (1)

Biological Activity

C-type natriuretic peptide (1-22) (human, rat, swine) is an endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.

Technical Data

M. Wt 2197.61
Formula C93H157N27O28S3
Sequence GLSKGCFGLKLDRIGSMSGLGC

(Modifications: Disulfide bridge: 6-22)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 127869-51-6
PubChem ID 16179407
InChI Key UHSBKBYWHCBDCJ-DYGWFTAGSA-N
Smiles [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID: 1309330

Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID: 17681481

Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID: 18006579


If you know of a relevant reference for C-type natriuretic peptide (1-22) (human, rat, swine), please let us know.

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Keywords: C-type natriuretic peptide (1-22) (human, rat, swine), C-type natriuretic peptide (1-22) (human, rat, swine) supplier, Endogenous, peptide, agonists, NPR2, ANP, Receptors, Atrial, Natriuretic, Peptide, Receptor, 3520, Tocris Bioscience

4 Citations for C-type natriuretic peptide (1-22) (human, rat, swine)

Citations are publications that use Tocris products. Selected citations for C-type natriuretic peptide (1-22) (human, rat, swine) include:

Hui et al (2021) Coordinated Formation of IMPDH2 Cytoophidium in Mouse Oocytes and Granulosa Cells. Front Cell Dev Biol 9 690536 PMID: 34124077

Zhen et al (2021) C-Type Natriuretic Peptide Ameliorates Vascular Injury and Improves Neurological Outcomes in Neonatal Hypoxic-Ischemic Brain Injury in Mice. Int J Mol Sci 22 PMID: 34445671

Stott et al (2015) Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension 65 676 PMID: 25547342

Lubo et al (2023) 3D doppler ultrasound imaging of cerebral blood flow for assessment of neonatal hypoxic-ischemic brain injury in mice. PLoS One 18 e0285434 PMID: 37159455


Do you know of a great paper that uses C-type natriuretic peptide (1-22) (human, rat, swine) from Tocris? Please let us know.

Reviews for C-type natriuretic peptide (1-22) (human, rat, swine)

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NP in vitro.
By Anonymous on 08/05/2018
Assay Type: In Vitro
Species: Human

Used in vitro to investigate different roles of NP family members.