C-type natriuretic peptide (1-22) (human, rat, swine)

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Cat.No. 3520 - C-type natriuretic peptide (1-22) (human, rat, swine) | Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys | CAS No. 127869-51-6
Description: Endogenous peptide agonist at NPR2
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.

Technical Data

M. Wt 2197.61
Formula C93H157N27O28S3
Sequence GLSKGCFGLKLDRIGSMSGLGC

(Modifications: Disulfide bridge between 6 - 22)

Storage Desiccate at -20°C
CAS Number 127869-51-6
PubChem ID 16179407
InChI Key UHSBKBYWHCBDCJ-DYGWFTAGSA-N
Smiles [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID: 1309330

Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID: 17681481

Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID: 18006579


If you know of a relevant reference for C-type natriuretic peptide (1-22) (human, rat, swine), please let us know.

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Keywords: C-type natriuretic peptide (1-22) (human, rat, swine), C-type natriuretic peptide (1-22) (human, rat, swine) supplier, Endogenous, peptide, agonists, NPR2, ANP, Receptors, Atrial, Natriuretic, Peptide, Receptor, 3520, Tocris Bioscience

1 Citation for C-type natriuretic peptide (1-22) (human, rat, swine)

Citations are publications that use Tocris products. Selected citations for C-type natriuretic peptide (1-22) (human, rat, swine) include:

Stott et al (2015) Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats. Hypertension 65 676 PMID: 25547342


Do you know of a great paper that uses C-type natriuretic peptide (1-22) (human, rat, swine) from Tocris? Please let us know.

Reviews for C-type natriuretic peptide (1-22) (human, rat, swine)

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NP in vitro
By Anonymous on 08/05/2018
Assay Type: In Vitro
Species: Human

Used in vitro to investigate different roles of NP family members.


Literature in this Area

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Cardiovascular

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  • Myocardial Infarction
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