Lactate Dehydrogenase A

Lactate Dehydrogenase A (LDHA; LDH5), EC 1.1.1.27, is one of five isoforms of the lactate dehydrogenase family. It catalyzes the conversion of pyruvate to lactate under anaerobic conditions and is key in the altered glycolytic metabolism that is a feature of cancer cells.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4795 Galloflavin
Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
5189 GSK 2837808A
Potent, selective LDHA inhibitor
5363 NHI 2
LDHA inhibitor

Lactate Dehydrogenase A (LDHA; LDH5), EC 1.1.1.27, is one of five isoforms of the lactate dehydrogenase family. It catalyzes the conversion of pyruvate to lactate under anaerobic conditions and plays a key role in the altered glycolytic metabolism that is a feature of cancer cells. LDHs are tetrameric enzymes comprising two different types of subunit, M and H; different combinations of these subunits result in five separate isoforms. LDHA, which is found mainly in skeletal muscle but also in tumors, consists of four M subunits.

LDHA is overexpressed in a wide range of tumors and is associated with the more aggressive cancer phenotypes and poor prognosis. Expression of LDHA is regulated by hypoxia inducible factor-1 (HIF-1) and the oncogene c-Myc. The enzyme is necessary for tumor maintenance, since cancer cells rely on glycolytic metabolism for energy, whereas it is not essential for normal healthy cells that rely on oxidative phosphorylation. Inhibition of LDHA has been shown in animal models to reduce tumor growth, increase oxidative stress and induce apoptosis. The enzyme is therefore being evaluated as a therapeutic target in cancer metabolism.

Literature for Lactate Dehydrogenase A

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Lactate Dehydrogenase A Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
LDHA Human LDHA NM_005566 P00338
Mouse Ldha NM_001136069 P06151
Rat Ldha NM_017025 P04642