LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 335.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.98 mL||14.91 mL||29.83 mL|
|5 mM||0.6 mL||2.98 mL||5.97 mL|
|10 mM||0.3 mL||1.49 mL||2.98 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172 PMID: 24178759
Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263 PMID: 24174263
Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588 PMID: 23986182
Jacobsen et al (2018) APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells. Cell Chem.Biol. 25 1337 PMID: 30122371
If you know of a relevant reference for NHI 2, please let us know.
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Keywords: NHI 2, NHI 2 supplier, NHI2, C17H12F3NO3, LDHA, inhibitors, lactate, dehydrogenases, antiproliferative, inhibits, Lactate, Dehydrogenase, A, 5363, Tocris Bioscience
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