Home / Pharmacology / Enzymes / Dehydrogenases / Lactate Dehydrogenase A / Lactate Dehydrogenase A Inhibitors / NHI 2

NHI 2

Cat. No. 5363 Submit a Review Datasheet / COA / SDS
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Description: LDHA inhibitor
Chemical Name: Methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for NHI 2

NHI 2 is an LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells. Also inhibits ferroptosis.

Compound Libraries for NHI 2

NHI 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NHI 2

M. Wt 335.28
Formula C17H12F3NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1269802-97-2
PubChem ID 51355147
InChI Key YPPFWRWCZNXINO-UHFFFAOYSA-N
Smiles ON2C1=CC(C3=CC=CC=C3)=CC(C(F)(F)F)=C1C=C2C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NHI 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.53 100
ethanol 33.53 100

Preparing Stock Solutions for NHI 2

The following data is based on the product molecular weight 335.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.83 mL
5 mM 0.6 mL 2.98 mL 5.97 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for NHI 2

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for NHI 2

References are publications that support the biological activity of the product.

Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcit. against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172 PMID: 24178759

Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263 PMID: 24174263

Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588 PMID: 23986182

Jacobsen et al (2018) APD-containing cyclolipodepsipeptides target mitochondrial function in hypoxic cancer cells. Cell Chem.Biol. 25 1337 PMID: 30122371

If you know of a relevant reference for NHI 2, please let us know.

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Citations for NHI 2

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Literature in this Area

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