Inositol Phosphatases

Inositol lipids are important intracellular second messengers. Inositol phosphatases remove phosphate groups from inositol lipids and are involved in the phosphatidylinositol signaling pathway. Two examples are Ins(1,4,5)P3 5-phosphatase and inositol monophosphatase.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3718 AS 1949490
SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor
1420 D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
Potent inhibitor of Ins(1,4,5)P3 5-phosphatase. Metabolite of Cat. No. 1482
0681 L-690,330
Inositol monophosphatase inhibitor

Other

Cat No Product Name / Activity
0682 L-690,488
Cell permeable prodrug of the IMPase inhibitor L-690,330 (Cat. No. 0681)

Inositol lipids are important intracellular second messengers. Inositol phosphatases remove phosphate groups from inositol lipids and are involved in the phosphatidylinositol signaling pathway. Two examples of inositol phosphatases are Ins(1,4,5)P3 5-phosphatase (E.C. 3.1.3.36) and inositol monophosphatase (IMPase) (E.C. 3.1.3.25).

Ins(1,4,5)P3 5-phosphatase catalyzes the specific dephosphorylation of Ins(1,4,5)P4 in the 5 position to form Ins(1,3,4)P3. This enzyme requires Mg2+ for catalytic activity and is found in almost all tissues.

IMPase is essential for the de novo synthesis of myo-inositol, and for recycling of Ins(1,4,5)P3. IMPases are regulated in response to the metabolic need of inositol lipids. Structurally, IMPase exists as a homodimer that requires two metal cations (Mn2+ or Ca2+) for catalytic activity. The human IMPase 2 gene has been localized to chromosome 18p11.2 and this has been identified as a susceptibility region for bipolar disorder, schizophrenia and febrile seizures.

Literature for Inositol Phosphatases

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Inositol Phosphatase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IMPase 1 Human IMPA1 NM_005536 P29218
Mouse Impa1 NM_018864 O55023
Rat Impa1 NM_032057 P97618
IMPase 2 Human IMPA2 NM_014214 O14732
Mouse Impa2 NM_053261 Q91UZ5
Rat Impa2 NM_172224 Q8CIN7
Inositol polyphosphate-1-phosphatase Human INPP1 NM_002194 P49441
Mouse Inpp1 NM_008384 P49442
Rat Inpp1 NM_001012131 Q5RJK6
Type I inositol polyphosphate-4-phosphatase Human INPP4A NM_001566 Q96PE3
Mouse Innp4a NM_030266 Q9EPW0
Rat Inpp4a NM_031002 Q62784
Type II inositol polyphosphate-4-phosphatase Human INPP4B NM_003866 O15327
Mouse Inpp4b NM_001024617 Q6P1Y8
Rat Inpp4b NM_053917 Q9QWG5
Inositol polyphosphate-5-phosphatase A Human INPP5A NM_005539 Q14642
Mouse Inpp5a NM_001127363 NP_898967
Rat Inpp5a NM_001108923 XP_344972
Inositol polyphosphate-5-phosphatase B Human INPP5B NM_005540 P32019
Mouse Inpp5b NM_008385 NP_032411
Rat Inpp5b NM_172224 Q8CIN7
Inositol polyphosphate-5-phosphatase D Human INPP5D NM_001017915 Q92835
Mouse Inpp5d NM_010566 Q9ES52
Rat Inpp5d NM_019311 P97573
Inositol polyphosphate-5-phosphatase E Human INPP5E NM_019892 Q9NRR6
Mouse Innp5e NM_033134 Q9JII1
Inositol polyphosphate-5-phosphatase F Human INPP5F NM_014937 Q9Y2H2
Mouse Inpp5f NM_178641 Q8CDA1
Rat Inpp5f NM_001107554 XP_219372
Inositol polyphosphate-5-phosphatase J Human INPP5J NM_001002837 Q15735
Mouse Inpp5j NM_172439 P59644
Rat Inpp5j NM_133562 Q9JMC1
Inositol polyphosphate-5-phosphatase K Human INPP5K NM_130766 Q9BT40
Mouse Inpp5k NM_008916 Q8C5L6
Rat Inpp5k NM_001013859 Q5XIU8
Inositol polyphosphate phosphatase-like 1 Human INPPL1 NM_001567 Y14385
Mouse Inppl1 NM_010567 Q6P549
Rat Inppl1 NM_022944 Q9WVR3