Hydroxylases

Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-β hydroxylase (E.C. 1.14.15.4), and LTB4 ω-hydroxylase (E.C. 1.14.13.30).

Products
Background
Gene Data

Inhibitors

Cat. No. Product Name / Activity
5953 Adaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
0938 p-Chlorophenylalanine
Tryptophan hydroxylase inhibitor
4408 DMOG
Prolyl hydroxylase inhibitor
4451 IOX 2
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
3292 Metyrapone
11-β hydroxylase inhibitor
5037 Nepicastat hydrochloride
Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable
0607 17-ODYA
LTB ω-hydroxylase inhibitor
5871 pCPA methyl ester hydrochloride
Tryptophan hydroxylase inhibitor
3254 Ro 61-8048
Potent kynurenine 3-monooxygenase (KMO) inhibitor
4926 UPF 648
Potent kynurenine 3-monooxygenase (KMO) inhibitor

Hydroxylases are enzymes that catalyze the addition of -OH (hydroxyl) groups to their substrate during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), which is involved in serotonin synthesis; steroid 11-β hydroxylase (also known as CYP11B1) (E.C. 1.14.15.4), which is involved in glucocorticoid synthesis; and LTB4 ω-hydroxylase (also known as CYP4F3) (E.C. 1.14.13.30), which is involved in arachidonic acid metabolism.

External sources of pharmacological information for Hydroxylases :

    Hydroxylase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    TPH1 Human TPH1 NM_004179 P17752
    Mouse Tph1 NM_009414 P17532
    Rat Tph1 NM_001100634 P09810
    TPH2 Human TPH2 NM_173353 Q8IWU9
    Mouse Tph2 NM_173391 Q8CGV2
    Rat Tph2 NM_173839 Q8CGU9
    CYP11B1 Human CYP11B1 NM_001026213 P15538
    Mouse Cyp11b1 NM_001033229 NP_001028401
    Rat Cyp11b1 NM_012537 P15393
    CYP4F3 Human CYP4F3 NM_000896 Q08477