Hydroxylases

Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-β hydroxylase (E.C. 1.14.15.4), and LTB4 ω-hydroxylase (E.C. 1.14.13.30).

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5953 Adaptaquin
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
0938 p-Chlorophenylalanine
Tryptophan hydroxylase inhibitor
4408 DMOG
Prolyl hydroxylase inhibitor
4451 IOX 2
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
3292 Metyrapone
11-β hydroxylase inhibitor
5037 Nepicastat hydrochloride
Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable
0607 17-ODYA
LTB ω-hydroxylase inhibitor
5871 pCPA methyl ester hydrochloride
Tryptophan hydroxylase inhibitor
3254 Ro 61-8048
Potent kynurenine 3-monooxygenase (KMO) inhibitor
4926 UPF 648
Potent kynurenine 3-monooxygenase (KMO) inhibitor

Hydroxylases are enzymes that catalyze the addition of -OH (hydroxyl) groups to their substrate during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), which is involved in serotonin synthesis; steroid 11-β hydroxylase (also known as CYP11B1) (E.C. 1.14.15.4), which is involved in glucocorticoid synthesis; and LTB4 ω-hydroxylase (also known as CYP4F3) (E.C. 1.14.13.30), which is involved in arachidonic acid metabolism.

Literature for Hydroxylases

Tocris offers the following scientific literature for Hydroxylases to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Hydroxylase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TPH1 Human TPH1 NM_004179 P17752
Mouse Tph1 NM_009414 P17532
Rat Tph1 NM_001100634 P09810
TPH2 Human TPH2 NM_173353 Q8IWU9
Mouse Tph2 NM_173391 Q8CGV2
Rat Tph2 NM_173839 Q8CGU9
CYP11B1 Human CYP11B1 NM_001026213 P15538
Mouse Cyp11b1 NM_001033229 NP_001028401
Rat Cyp11b1 NM_012537 P15393
CYP4F3 Human CYP4F3 NM_000896 Q08477