Hydroxylases are enzymes that catalyze the addition of hydroxyl groups to substrates during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), steroid 11-β hydroxylase (E.C. 1.14.15.4), and LTB4 ω-hydroxylase (E.C. 1.14.13.30).
Inhibitors |
|
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Cat No | Product Name / Activity |
5953 | Adaptaquin |
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant | |
0938 | p-Chlorophenylalanine |
Tryptophan hydroxylase inhibitor | |
4408 | DMOG |
Prolyl hydroxylase inhibitor | |
4451 | IOX 2 |
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor | |
3292 | Metyrapone |
11-β hydroxylase inhibitor | |
5037 | Nepicastat hydrochloride |
Potent and selective dopamine β-hydroxylase (DBH) inhibitor; orally bioavailable | |
0607 | 17-ODYA |
LTB ω-hydroxylase inhibitor | |
5871 | pCPA methyl ester hydrochloride |
Tryptophan hydroxylase inhibitor | |
3254 | Ro 61-8048 |
Potent kynurenine 3-monooxygenase (KMO) inhibitor | |
4926 | UPF 648 |
Potent kynurenine 3-monooxygenase (KMO) inhibitor |
Hydroxylases are enzymes that catalyze the addition of -OH (hydroxyl) groups to their substrate during oxidation reactions. This diverse group of enzymes includes tryptophan hydroxylase (E.C. 1.14.16.4), which is involved in serotonin synthesis; steroid 11-β hydroxylase (also known as CYP11B1) (E.C. 1.14.15.4), which is involved in glucocorticoid synthesis; and LTB4 ω-hydroxylase (also known as CYP4F3) (E.C. 1.14.13.30), which is involved in arachidonic acid metabolism.
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
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TPH1 | Human | TPH1 | NM_004179 | P17752 |
Mouse | Tph1 | NM_009414 | P17532 | |
Rat | Tph1 | NM_001100634 | P09810 | |
TPH2 | Human | TPH2 | NM_173353 | Q8IWU9 |
Mouse | Tph2 | NM_173391 | Q8CGV2 | |
Rat | Tph2 | NM_173839 | Q8CGU9 | |
CYP11B1 | Human | CYP11B1 | NM_001026213 | P15538 |
Mouse | Cyp11b1 | NM_001033229 | NP_001028401 | |
Rat | Cyp11b1 | NM_012537 | P15393 | |
CYP4F3 | Human | CYP4F3 | NM_000896 | Q08477 |