Pricing Availability   Qty
Description: Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for IOX 2

IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

Compound Libraries for IOX 2

IOX 2 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for IOX 2

M. Wt 352.34
Formula C19H16N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 931398-72-0
PubChem ID 54685215
Smiles OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IOX 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.23 100

Preparing Stock Solutions for IOX 2

The following data is based on the product molecular weight 352.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for IOX 2

References are publications that support the biological activity of the product.

Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676 PMID: 20666436

If you know of a relevant reference for IOX 2, please let us know.

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2 Citations for IOX 2

Citations are publications that use Tocris products. Selected citations for IOX 2 include:

Navdeep S et al (2021) Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway. Cell Rep 36 109547 PMID: 34407414

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

Do you know of a great paper that uses IOX 2 from Tocris? Please let us know.

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