IOX 2

Pricing Availability Delivery Time Qty
Cat.No. 4451 - IOX 2 | C19H16N2O5 | CAS No. 931398-72-0
Description: Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3. Cell permeable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 2 probe summary on the SGC website.

Compound Libraries

IOX 2 is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 352.34
Formula C19H16N2O5
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 931398-72-0
PubChem ID 54685215
InChI Key CAOSCCRYLYQBES-UHFFFAOYSA-N
Smiles OC(C1=CC=CC=C1N2CC3=CC=CC=C3)=C(C(NCC(O)=O)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 352.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Murray et al (2010) Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity. J.Comb.Chem. 12 676 PMID: 20666436


If you know of a relevant reference for IOX 2, please let us know.

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Keywords: supplier IOX2 hypoxia inducible factor 1 alpha 1a HIF1a HIF1alpha prolyl hydroxylases potent inhibits inhibitors selective cell permeable epigenetics probe JICL38 sgc PHD2 Hydroxylases

Citations for IOX 2

Citations are publications that use Tocris products.

Currently there are no citations for IOX 2. Do you know of a great paper that uses IOX 2 from Tocris? If so please let us know.

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for IOX 2

Protocols

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