pCPA methyl ester hydrochloride

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Cat.No. 5871 - pCPA methyl ester hydrochloride | C10H12ClNO2.HCl | CAS No. 14173-40-1
Description: Tryptophan hydroxylase inhibitor
Chemical Name: 4-Chloro-DL-Phenylalanine methyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Tryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).

Technical Data

M. Wt 250.12
Formula C10H12ClNO2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 14173-40-1
PubChem ID 26531
InChI Key GCBCWTWQAFLKJG-UHFFFAOYSA-N
Smiles O=C(C(CC1=CC=C(C=C1)Cl)N)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.01 100
ethanol 25.01 100
water 25.01 100

Preparing Stock Solutions

The following data is based on the product molecular weight 250.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.99 mL 39.98 mL
5 mM 0.8 mL 4 mL 8 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pinto Brod et al (2016) Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 65 201 PMID: 26596986

Wallace et al (2014) Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 17 1695 PMID: 24852131


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