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Description: Prolyl hydroxylase inhibitor
Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Purity: ≥97% (HPLC)
Citations (3)
Reviews (2)

Biological Activity for DMOG

DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.

Technical Data for DMOG

M. Wt 175.14
Formula C6H9NO5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 89464-63-1
PubChem ID 560326
Smiles O=C(C(OC)=O)NCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMOG

Solvent Max Conc. mg/mL Max Conc. mM
water 17.51 100
DMSO 17.51 100

Preparing Stock Solutions for DMOG

The following data is based on the product molecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.55 mL 57.1 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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Product Datasheets for DMOG

Certificate of Analysis / Product Datasheet
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Keywords: DMOG, DMOG supplier, prolyl, 4-hydoxylase, P4H, inhibitors, inhibits, HIF, hypoxia-inducible, factors, 1a, 1alpha, 1α, proangiogenic, prolylhydroxylases, PHD, Hydroxylases, Hypoxia, Inducible, Factors, 4408, Tocris Bioscience

3 Citations for DMOG

Citations are publications that use Tocris products. Selected citations for DMOG include:

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Wiktoria et al (2022) Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Br J Cancer 127 1365-1377 PMID: 35840734

Izzie Jacques et al (2022) Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv 8 eabo2295 PMID: 35867798

Do you know of a great paper that uses DMOG from Tocris? Please let us know.

Reviews for DMOG

Average Rating: 5 (Based on 2 Reviews.)

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By shubham dubey on 12/22/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: A549

IN cell culture to stabilize HIF1

review image

Good product.
By P Kumar on 05/27/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: A549

To check the HIF2a activity in A549 cells.

review image