DMOG

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Cat.No. 4408 - DMOG | C6H9NO5 | CAS No. 89464-63-1
Description: Prolyl hydroxylase inhibitor
Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Datasheet
Citations
Literature

Biological Activity

Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.

Technical Data

M. Wt 175.14
Formula C6H9NO5
Storage Store at -20°C
CAS Number 89464-63-1
PubChem ID 560326
InChI Key BNJOZDZCRHCODO-UHFFFAOYSA-N
Smiles O=C(C(OC)=O)NCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.51 100
ethanol 17.51 100
water 17.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.55 mL 57.1 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ayrapetov et al (2011) Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 6 e26064 PMID: 22016813

Jaakkola et al (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468 PMID: 11292861

Lomb et al (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne Mol.Pharmacol. 75 1198 PMID: 19204094

Barnucz et al (2013) Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 345 25 PMID: 23388095


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Keywords: prolyl 4-hydoxylase P4H inhibitors inhibits HIF hypoxia-inducible factors 1a 1alpha 1α proangiogenic prolylhydroxylases PHD Hydroxylases

Citations for DMOG

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