DMOG

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Cat.No. 4408 - DMOG | C6H9NO5 | CAS No. 89464-63-1
Description: Prolyl hydroxylase inhibitor
Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions.

Technical Data

M. Wt 175.14
Formula C6H9NO5
Storage Store at -20°C
CAS Number 89464-63-1
PubChem ID 560326
InChI Key BNJOZDZCRHCODO-UHFFFAOYSA-N
Smiles O=C(C(OC)=O)NCC(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.51 100
DMSO 17.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.55 mL 57.1 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: DMOG, DMOG supplier, prolyl, 4-hydoxylase, P4H, inhibitors, inhibits, HIF, hypoxia-inducible, factors, 1a, 1alpha, 1α, proangiogenic, prolylhydroxylases, PHD, Hydroxylases, Hypoxia, Inducible, Factors, 4408, Tocris Bioscience

1 Citation for DMOG

Citations are publications that use Tocris products. Selected citations for DMOG include:

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329


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Literature in this Area

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