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DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.71 mL||28.55 mL||57.1 mL|
|5 mM||1.14 mL||5.71 mL||11.42 mL|
|10 mM||0.57 mL||2.85 mL||5.71 mL|
|50 mM||0.11 mL||0.57 mL||1.14 mL|
References are publications that support the biological activity of the product.
Ayrapetov et al (2011) Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 6 e26064 PMID: 22016813
Jaakkola et al (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468 PMID: 11292861
Lomb et al (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic ne Mol.Pharmacol. 75 1198 PMID: 19204094
Barnucz et al (2013) Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 345 25 PMID: 23388095
Jackson et al (2017) Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res 21 124 PMID: 28445828
If you know of a relevant reference for DMOG, please let us know.
Keywords: DMOG, DMOG supplier, prolyl, 4-hydoxylase, P4H, inhibitors, inhibits, HIF, hypoxia-inducible, factors, 1a, 1alpha, 1α, proangiogenic, prolylhydroxylases, PHD, Hydroxylases, Hypoxia, Inducible, Factors, 4408, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for DMOG include:
Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329
Do you know of a great paper that uses DMOG from Tocris? Please let us know.
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IN cell culture to stabilize HIF1