You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for Nepicastat hydrochloride
Nepicastat hydrochloride is a potent and selective dopamine β-hydroxylase (DBH) inhibitor (IC50 = 9 nM). Selective for DBH over 12 other enzymes. Decreases noradrenaline and increases dopamine levels in tissues and plasma in hypertensive rats. Prevents progressive left ventricular dysfunction in an in vivo heart failure model. Also potentiates the stimulus effects of cocaine without producing cocaine-like effects in rats. Orally bioavailable.
Technical Data for Nepicastat hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nepicastat hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Nepicastat hydrochloride
The following data is based on the product molecular weight 331.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.01 mL||15.07 mL||30.14 mL|
|5 mM||0.6 mL||3.01 mL||6.03 mL|
|10 mM||0.3 mL||1.51 mL||3.01 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
Product Datasheets for Nepicastat hydrochloride
References for Nepicastat hydrochloride
References are publications that support the biological activity of the product.
Manvich et al (2013) DA β-hydroxylase inhibitors enhance the discriminative stimulus effects of cocaine in rats. J.Pharmacol.Exp.Ther. 347 564 PMID: 24068832
Sabbah et al (2000) Effects of DA β-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation 102 1990 PMID: 11034950
Stanley et al (1997) Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of DA-beta-hydroxylase. Br.J.Pharmacol. 121 1803 PMID: 9283721
If you know of a relevant reference for Nepicastat hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Nepicastat hydrochloride, Nepicastat hydrochloride supplier, dopamine, beta-hydroxylase, inhibitors, inhibits, β, B-hydroxylase, DBH, noradrenaline, norepinephrine, potent, selective, orally, bioavailable, Hydroxylases, 5037, Tocris Bioscience
Citations for Nepicastat hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Nepicastat hydrochloride. Do you know of a great paper that uses Nepicastat hydrochloride from Tocris? Please let us know.
Reviews for Nepicastat hydrochloride
There are currently no reviews for this product. Be the first to review Nepicastat hydrochloride and earn rewards!
Have you used Nepicastat hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image