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Description: HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity: ≥97% (HPLC)
Citations (1)

Biological Activity for Adaptaquin

Adaptaquin is a HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.

Technical Data for Adaptaquin

M. Wt 377.82
Formula C21H16ClN3O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 385786-48-1
PubChem ID 3740671
Smiles OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Adaptaquin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.78 100

Preparing Stock Solutions for Adaptaquin

The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for Adaptaquin

References are publications that support the biological activity of the product.

Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29 PMID: 26936506

Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214 PMID: 27148687

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Keywords: Adaptaquin, Adaptaquin supplier, HIF-PHD, inhibitors, hypoxia, inducible, factor, prolyl, hydroxylases, inhibits, antioxidant, neuroprotective, brain, penetrant., Hypoxia, Inducible, Factors, Hydroxylases, 5953, Tocris Bioscience

1 Citation for Adaptaquin

Citations are publications that use Tocris products. Selected citations for Adaptaquin include:

Saravanan S et al (2021) HIF1α stabilization in hypoxia is not oxidant-initiated. Elife 10 PMID: 34596045

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