Adaptaquin

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Cat.No. 5953 - Adaptaquin | C21H16ClN3O2 | CAS No. 385786-48-1
Description: HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Chemical Name: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

HIF-prolyl hydroxylase-2 (PHD2) inhibitor. Blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. Exhibits neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Brain penetrant. Also antioxidant.

Technical Data

M. Wt 377.82
Formula C21H16ClN3O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 385786-48-1
PubChem ID 3740671
InChI Key KKYHNYRUBSYTCZ-UHFFFAOYSA-N
Smiles OC1=C(N=CC=C1)NC(C2=C(C3=C(C=C2)C=CC=N3)O)C4=CC=C(C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References

References are publications that support the products' biological activity.

Karuppagounder et al (2016) Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci.Transl.Med. 8 328ra29 PMID: 26936506

Neitemeier et al (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 7 e2214 PMID: 27148687


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Keywords: HIF-PHD inhibitors hypoxia inducible factor prolyl hydroxylases inhibits antioxidant neuroprotective brain penetrant. Hydroxylases

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