p-Chlorophenylalanine

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Cat.No. 0938 - p-Chlorophenylalanine | C9H10ClNO2 | CAS No. 7424-00-2
Description: Tryptophan hydroxylase inhibitor
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data

M. Wt 199.64
Formula C9H10ClNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 7424-00-2
PubChem ID 4652
InChI Key NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles NC(C(O)=O)CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Datla and Curzon (1996) Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 315 PMID: 8783206

Koyuncuoglu et al (1975) The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 45 163 PMID: 129787


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Keywords: p-Chlorophenylalanine, p-Chlorophenylalanine supplier, Tryptophan, hydroxylases, inhibitors, inhibits, serotonin, depletion, PCPA, fenclonine, 5-HT-Related, Hydroxylases, 5-HT3, Receptors, 0938, Tocris Bioscience

2 Citations for p-Chlorophenylalanine

Citations are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:

Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A 302 E1009 PMID: 22318950

Tullius et al (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5 5101 PMID: 25290058


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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