p-Chlorophenylalanine

Pricing Availability Delivery Time Qty
Cat.No. 0938 - p-Chlorophenylalanine | C9H10ClNO2 | CAS No. 7424-00-2
Description: Tryptophan hydroxylase inhibitor
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data

M. Wt 199.64
Formula C9H10ClNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 7424-00-2
PubChem ID 4652
InChI Key NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles NC(C(O)=O)CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 199.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.01 mL 25.05 mL 50.09 mL
5 mM 1 mL 5.01 mL 10.02 mL
10 mM 0.5 mL 2.5 mL 5.01 mL
50 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Datla and Curzon (1996) Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 35 315 PMID: 8783206

Koyuncuoglu et al (1975) The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 45 163 PMID: 129787


If you know of a relevant reference for p-Chlorophenylalanine, please let us know.

View Related Products by Product Action

View all Hydroxylase Inhibitors

Keywords: Tryptophan hydroxylases inhibitors inhibits serotonin depletion PCPA fenclonine Hydroxylases

2 Citations for p-Chlorophenylalanine

Citations are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:

Tullius et al (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5 5101 PMID: 25290058

Hernandez et al (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A 302 E1009 PMID: 22318950


Do you know of a great paper that uses p-Chlorophenylalanine from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for p-Chlorophenylalanine

Protocols

TODO: Add Protocols