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Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require either pyridoxal phosphate or pyruvate as a co-factor. Decarboxylases are known for their various roles in metabolic pathways and carbohydrate synthesis.
Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require pyridoxal phosphate or pyruvate as a co-factor. They are known for their various roles in metabolic pathways, non-oxidative decarboxylation of α- and β-keto acids and carbohydrate synthesis.
There are multiple members of this group, including ornithine decarboxylase (ODC) (EC: 126.96.36.199), which is involved in the urea cycle and L-aromatic amino-acid decarboxylase (AADC) (EC: 188.8.131.52), which is involved in conversion of L-dopa to dopamine and 5-HTP to serotonin.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
ODC, Ornithine decarboxylase; AADC, L-Aromatic amino-acid decarboxylase; SAMDC, S-Adenosylmethionine decarboxylase; ADC, L-Arginine decarboxylase; GAD, Glutamic acid decarboxylase; HDC, Histidine decarboxylase; PSDC, Phosphatidylserine decarboxylase.