Decarboxylases

Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require either pyridoxal phosphate or pyruvate as a co-factor. Decarboxylases are known for their various roles in metabolic pathways and carbohydrate synthesis.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
0455 (S)-(-)-Carbidopa
Aromatic L-amino acid decarboxylase inhibitor
6319 CBM 301940
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
2761 DFMO
Ornithine decarboxylase inhibitor
0584 L-(-)-α-Methyldopa
Aromatic L-amino acid decarboxylase inhibitor

Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require pyridoxal phosphate or pyruvate as a co-factor. They are known for their various roles in metabolic pathways, non-oxidative decarboxylation of α- and β-keto acids and carbohydrate synthesis.

There are multiple members of this group, including ornithine decarboxylase (ODC) (EC: 4.1.1.17), which is involved in the urea cycle and L-aromatic amino-acid decarboxylase (AADC) (EC: 4.1.1.28), which is involved in conversion of L-dopa to dopamine and 5-HTP to serotonin.

External sources of pharmacological information for Decarboxylases :

Literature for Decarboxylases

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Decarboxylase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ODC Human ODC1 NM_002539 P11926
Mouse Odc1 NM_013614 P00860
Rat Odc1 NM_012615 P09057
AADC Human DDC NM_001082971 P20711
Mouse Ddc NM_016672 O88533
Rat Ddc NM_016672 Q3TUH2
SAMDC Human AMD1 NM_001033059 P17707
Mouse Amd1 NM_009665 P31154
Rat Amd1 NM_031011 P17708
ADC Human ADC NM_052998 Q96L57
Mouse Adc NM_172875 Q8BVM4
Rat Adc NM_172875 Q6P078
GAD1 Human GAD1 NM_013445 Q99259
Mouse Gad1 NM_008077 P48318
Rat Gad1 NM_017007 Q63211
GAD2 Human GAD2 NM_000818 Q05329
Mouse Gad2 NM_008078 P48320
Rat Gad2 NM_012563 Q71UF5
HDC Human HDC NM_002112 P19113
Mouse Hdc NM_008230 P23738
Rat Hdc NM_017016 P16453
PSDC Human PISD NM_014338 Q9UG56
Mouse Pisd NM_177298 Q8BSF4
Rat Pisd XM_001066221 XP_001061408

ODC, Ornithine decarboxylase; AADC, L-Aromatic amino-acid decarboxylase; SAMDC, S-Adenosylmethionine decarboxylase; ADC, L-Arginine decarboxylase; GAD, Glutamic acid decarboxylase; HDC, Histidine decarboxylase; PSDC, Phosphatidylserine decarboxylase.