You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for CBM 301940
CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.
Compound Libraries for CBM 301940
Technical Data for CBM 301940
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CBM 301940
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CBM 301940
The following data is based on the product molecular weight 422.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.37 mL||11.84 mL||23.68 mL|
|5 mM||0.47 mL||2.37 mL||4.74 mL|
|10 mM||0.24 mL||1.18 mL||2.37 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References for CBM 301940
References are publications that support the biological activity of the product.
Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID: 15105298
Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID: 16821767
If you know of a relevant reference for CBM 301940, please let us know.
View Related Products by Product Action
Keywords: CBM 301940, CBM 301940 supplier, CBM301940, MCD, malonyl, coenzyme, A, CoA, inhibitors, inhibits, potent, orally, bioavailable, Decarboxylases, Other, Lipid, Metabolism, 6319, Tocris Bioscience
Citations for CBM 301940
Citations are publications that use Tocris products.
Currently there are no citations for CBM 301940. Do you know of a great paper that uses CBM 301940 from Tocris? Please let us know.
Reviews for CBM 301940
There are currently no reviews for this product. Be the first to review CBM 301940 and earn rewards!
Have you used CBM 301940?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image