CBM 301940

Pricing Availability   Qty
Description: Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Chemical Name: tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
Purity: ≥98% (HPLC)

Biological Activity for CBM 301940

CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

Compound Libraries for CBM 301940

CBM 301940 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CBM 301940

M. Wt 422.32
Formula C15H20F6N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 902146-11-6
PubChem ID 10387489
Smiles CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CBM 301940

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.23 100
ethanol 42.23 100

Preparing Stock Solutions for CBM 301940

The following data is based on the product molecular weight 422.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for CBM 301940

References are publications that support the biological activity of the product.

Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID: 15105298

Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID: 16821767

If you know of a relevant reference for CBM 301940, please let us know.

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Citations for CBM 301940

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