CBM 301940

Pricing Availability   Qty
Cat.No. 6319 - CBM 301940 | C15H20F6N2O5 | CAS No. 902146-11-6
Description: Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Chemical Name: tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

Technical Data

M. Wt 422.32
Formula C15H20F6N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 902146-11-6
PubChem ID 10387489
InChI Key SBPVPWWNQIKSKL-UHFFFAOYSA-N
Smiles CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.23 100
ethanol 42.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 422.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.84 mL 23.68 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

Dyck et al (2004) Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 94 e78 PMID: 15105298

Cheng et al (2006) Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 49 4055 PMID: 16821767


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Keywords: CBM 301940, CBM 301940 supplier, CBM301940, MCD, malonyl, coenzyme, A, CoA, inhibitors, inhibits, potent, orally, bioavailable, Decarboxylases, Other, Lipid, Metabolism, 6319, Tocris Bioscience

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