Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 218.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.57 mL||22.87 mL||45.74 mL|
|5 mM||0.91 mL||4.57 mL||9.15 mL|
|10 mM||0.46 mL||2.29 mL||4.57 mL|
|50 mM||0.09 mL||0.46 mL||0.91 mL|
References are publications that support the biological activity of the product.
Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353 PMID: 17371277
Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663
Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693 PMID: 22132744
If you know of a relevant reference for DFMO, please let us know.
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Keywords: DFMO, DFMO supplier, Ornithine, decarboxylases, inhibitors, inhibits, Eflornithine, Decarboxylases, 2761, Tocris Bioscience
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Literature in this Area
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