Pricing Availability   Qty
Description: Ornithine decarboxylase inhibitor
Alternative Names: Eflornithine
Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride
Citations (1)

Biological Activity for DFMO

DFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data for DFMO

M. Wt 218.63
Formula C6H12F2N2O2.HCl
Storage Desiccate at RT
CAS Number 68278-23-9
PubChem ID 57004
Smiles NC(C(F)F)(C(O)=O)CCCN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DFMO

Solvent Max Conc. mg/mL Max Conc. mM
water 16.4 75

Preparing Stock Solutions for DFMO

The following data is based on the product molecular weight 218.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 6.1 mL 30.49 mL 60.99 mL
3.75 mM 1.22 mL 6.1 mL 12.2 mL
7.5 mM 0.61 mL 3.05 mL 6.1 mL
37.5 mM 0.12 mL 0.61 mL 1.22 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for DFMO

Certificate of Analysis / Product Datasheet
Select another batch:

References for DFMO

References are publications that support the biological activity of the product.

Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353 PMID: 17371277

Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663

Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693 PMID: 22132744

If you know of a relevant reference for DFMO, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Decarboxylase Inhibitors

Keywords: DFMO, DFMO supplier, Ornithine, decarboxylases, inhibitors, inhibits, Eflornithine, Decarboxylases, 2761, Tocris Bioscience

1 Citation for DFMO

Citations are publications that use Tocris products. Selected citations for DFMO include:

Machado et al (2021) Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 28 1 PMID: 33609440

Do you know of a great paper that uses DFMO from Tocris? Please let us know.

Reviews for DFMO

There are currently no reviews for this product. Be the first to review DFMO and earn rewards!

Have you used DFMO?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review