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Cat.No. 2761 - DFMO | C6H12F2N2O2.HCl | CAS No. 68278-23-9
Description: Ornithine decarboxylase inhibitor
Alternative Names: Eflornithine
Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride

Biological Activity

Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data

M. Wt 218.63
Formula C6H12F2N2O2.HCl
Storage Desiccate at RT
CAS Number 68278-23-9
PubChem ID 57004
Smiles NC(C(F)F)(C(O)=O)CCCN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 16.4 75

Preparing Stock Solutions

The following data is based on the product molecular weight 218.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.57 mL 22.87 mL 45.74 mL
5 mM 0.91 mL 4.57 mL 9.15 mL
10 mM 0.46 mL 2.29 mL 4.57 mL
50 mM 0.09 mL 0.46 mL 0.91 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353 PMID: 17371277

Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663 PMID:

Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693 PMID: 22132744

If you know of a relevant reference for DFMO, please let us know.

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Keywords: DFMO, supplier, Ornithine, decarboxylases, inhibitors, inhibits, Eflornithine, Decarboxylases, Decarboxylases, Tocris Bioscience

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