(S)-(-)-Carbidopa

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Cat.No. 0455 - (S)-(-)-Carbidopa | C10H14N2O4 | CAS No. 28860-95-9
Description: Aromatic L-amino acid decarboxylase inhibitor
Chemical Name: (S)-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity

Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

Technical Data

M. Wt 226.23
Formula C10H14N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 28860-95-9
PubChem ID 34359
InChI Key TZFNLOMSOLWIDK-JTQLQIEISA-N
Smiles OC1=C(O)C=CC(C[C@@](NN)(C)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.52 20

Preparing Stock Solutions

The following data is based on the product molecular weight 226.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 22.1 mL 110.51 mL 221.01 mL
1 mM 4.42 mL 22.1 mL 44.2 mL
2 mM 2.21 mL 11.05 mL 22.1 mL
10 mM 0.44 mL 2.21 mL 4.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cheng et al (1992) Carbidopa inhibition of aromatic L-amino acid decarboxylase in rat brain capilliaries. FASEB J. 6 A1589

Kopfhammer et al (1985) L-Dopa infusion experiments in combination with the L-dopa decarboxylase inhibitors benserazide and carb. - L-dopa metabolism and neuroendocrinological effects. Pharmacopsychiatry 18 143

Merck Index 12 1843


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Keywords: (S)-(-)-Carbidopa, (S)-(-)-Carbidopa supplier, Aromatic, Lamino, acid, decarboxylase, inhibitors, inhibits, Decarboxylases, Dopaminergic-Related, 0455, Tocris Bioscience

Citations for (S)-(-)-Carbidopa

Citations are publications that use Tocris products.

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Reviews for (S)-(-)-Carbidopa

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Carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine.
By Provs Pantha on 08/16/2019
Species: Human

Carbidopa acts as a peripheral DDC inhibitor, and carbidopa was used to understand it's effect on brain DDC conversion of levodopa/L-DOPA to dopamine.

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Literature in this Area

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