(S)-(-)-Carbidopa

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Cat.No. 0455 - (S)-(-)-Carbidopa | C10H14N2O4 | CAS No. 28860-95-9
Description: Aromatic L-amino acid decarboxylase inhibitor
Chemical Name: (S)-α-Hydrazino-α-methyl-β-(3,4-dihydroxyphenyl)propionic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

Technical Data

M. Wt 226.23
Formula C10H14N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 28860-95-9
PubChem ID 34359
InChI Key TZFNLOMSOLWIDK-JTQLQIEISA-N
Smiles OC1=C(O)C=CC(C[C@@](NN)(C)C(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.52 20

Preparing Stock Solutions

The following data is based on the product molecular weight 226.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.1 mL 44.2 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cheng et al (1992) Carbidopa inhibition of aromatic L-amino acid decarboxylase in rat brain capilliaries. FASEB J. 6 A1589 PMID:

Kopfhammer et al (1985) L-Dopa infusion experiments in combination with the L-dopa decarboxylase inhibitors benserazide and carbidopa - L-dopa metabolism and neuroendocrinological effects. Pharmacopsychiatry 18 143 PMID:

Merck Index 12 1843 PMID:


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Keywords: (S)-(-)-Carbidopa, supplier, Aromatic, Lamino, acid, decarboxylase, inhibitors, inhibits, Decarboxylases, Tocris Bioscience

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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for (S)-(-)-Carbidopa

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