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Submit ReviewR 7050
Description: Inhibitor of TNF-α receptor 1 signaling
Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Purity: ≥98% (HPLC)
Biological Activity for R 7050
R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
Technical Data for R 7050
| M. Wt | 380.77 |
| Formula | C16H8ClF3N4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 303997-35-5 |
| PubChem ID | 1486608 |
| InChI Key | SUUMKHOVGVYGOP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for R 7050
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.62 | 20 |
Preparing Stock Solutions for R 7050
The following data is based on the product molecular weight 380.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.13 mL | 65.66 mL | 131.31 mL |
| 1 mM | 2.63 mL | 13.13 mL | 26.26 mL |
| 2 mM | 1.31 mL | 6.57 mL | 13.13 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
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Product Datasheets for R 7050
References for R 7050
References are publications that support the biological activity of the product.
Gururaja et al (2007) A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chem.Biol. 14 1105 PMID: 17961823
King et al (2013) TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neurosci.Lett. 542 92 PMID: 23499961
If you know of a relevant reference for R 7050, please let us know.
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Keywords: R 7050, R 7050 supplier, R7050, tumor, necrosis, TNFa, TNFalpha, TNFα, inhibitors, inhibits, signaling, cytokines, receptors, Cytokine, Receptors, 5432, Tocris Bioscience
3 Citations for R 7050
Citations are publications that use Tocris products. Selected citations for R 7050 include:
Dominic et al (2020) Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering. ACS Nano 14 10027-10044 PMID: 32658450
Gonzalez-Juarbe et al (2017) Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ 24 917 PMID: 28387756
Vicente et al (2022) Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. Int J Mol Sci 23 PMID: 36233065
Do you know of a great paper that uses R 7050 from Tocris? Please let us know.
Reviews for R 7050
Average Rating: 5 (Based on 1 Review.)
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R 7050 inhibits 15d-PGJ2 induced caspase activation.
By
Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: HL-1 cardiomyocytes
HL-1 cells were incubated with R 7050 (30 μM) for 30 min prior to 15d-PGJ2 (15 μM) treatments for 4 h to follow markers of apoptosis. Pharmacological antagonism of TNF receptor inhibited 15d-PGJ2-induced caspase 3/8/9 activation (shown in Image).
