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Description: CD40-TRAF6 interaction inhibitor
Chemical Name: 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Purity: ≥99% (HPLC)

Biological Activity for 6877002

6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

Technical Data for 6877002

M. Wt 251.32
Formula C17H17NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 433249-94-6
PubChem ID 2291556
Smiles CC1=CC=C(C)C(N/C=C/C(C2=CC=CC=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 6877002

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.13 100
ethanol 25.13 100

Preparing Stock Solutions for 6877002

The following data is based on the product molecular weight 251.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.89 mL 39.79 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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References for 6877002

References are publications that support the biological activity of the product.

Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686 PMID: 24492375

If you know of a relevant reference for 6877002, please let us know.

View Related Products by Target

Keywords: 6877002, 6877002 supplier, cd40, traf6, tnfalpha, tnfa, tnfα, superfamily, cytokines, receptors, inhibitors, inhibits, inflammation, obesity, diabetes, insulin, Cytokine, Receptors, 5602, Tocris Bioscience

Citations for 6877002

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