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Biological Activity for 6877002
6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.
Technical Data for 6877002
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 6877002
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 6877002
The following data is based on the product molecular weight 251.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.98 mL||19.89 mL||39.79 mL|
|5 mM||0.8 mL||3.98 mL||7.96 mL|
|10 mM||0.4 mL||1.99 mL||3.98 mL|
|50 mM||0.08 mL||0.4 mL||0.8 mL|
References for 6877002
References are publications that support the biological activity of the product.
Chatzigeorgiou et al (2014) Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance. Proc.Natl.Acad.Sci.U.S.A. 111 2686 PMID: 24492375
If you know of a relevant reference for 6877002, please let us know.
Keywords: 6877002, 6877002 supplier, cd40, traf6, tnfalpha, tnfa, tnfα, superfamily, cytokines, receptors, inhibitors, inhibits, inflammation, obesity, diabetes, insulin, Cytokine, Receptors, 5602, Tocris Bioscience
Citations for 6877002
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Literature in this Area
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