EM 163

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Cat.No. 7010 - EM 163 | C44H60IN5O4 | CAS No. 1206480-93-4
Description: TIR-TIR interaction inhibitor
Chemical Name: 1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for EM 163

EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).

Technical Data for EM 163

M. Wt 849.9
Formula C44H60IN5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1206480-93-4
PubChem ID 44602511
InChI Key WJCJDZIXEVJIKZ-OFUZFLEOSA-M
Smiles CC([C@@H](C(N1CCCC1)=O)N(C(C2=C[N+](C)=C(C(N([C@H](C(N3CCCC3)=O)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)=O)CCCC5=CC=CC=C5)C.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EM 163

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 84.99 100

Preparing Stock Solutions for EM 163

The following data is based on the product molecular weight 849.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.18 mL 5.88 mL 11.77 mL
5 mM 0.24 mL 1.18 mL 2.35 mL
10 mM 0.12 mL 0.59 mL 1.18 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References for EM 163

References are publications that support the biological activity of the product.

Prieto et al (2019) Inhibition of LTP-induced translation by IL-1β reduces the level of newly synthesized proteins in hippocampal dendrites. ACS Chem.Neurosci. 20 1197 PMID: 30695637

Kissner et al (2012) Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One 7 e40773 PMID: 22848400

Lucas and Maes (2013) Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol.Neurobiol. 48 190 PMID: 23436141


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Keywords: EM 163, EM 163 supplier, EM163, inhibitors, inhibits, Cytokines, cytokines, MyD88, anti-inflammatory, interleukin-1, TIR, IL-1, Cytokine, Receptors, 7010, Tocris Bioscience

Citations for EM 163

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