CaV2.x Channels

CaV2.x channels are high-voltage activated calcium channels that are insensitive to blockade by dihydropyridines. There are three members in this family, which all show high expression in the central and peripheral nervous systems, where they mediate neurotransmitter release and are critical to neurotransmission.

Products
Background
Literature
Gene Data

Activators

Cat No Product Name / Activity
2851 Nefiracetam
CaV1.x and CaV2.2 activator; cognitive enhancer

Blockers

Cat No Product Name / Activity
2799 ω-Agatoxin IVA
CaV2.1 blocker
2802 ω-Agatoxin TK
CaV2.1 blocker
2629 Cilnidipine
Dual CaV1.x and CaV2.x blocker
1085 ω-Conotoxin GVIA
CaV2.2 blocker
1084 ω-Conotoxin MVIIC
CaV2.x blocker
5235 Huwentoxin XVI
Potent and reversible CaV2.2 blocker
0840 Loperamide hydrochloride
CaV1.x and CaV2.x blocker; also peripherally acting μ agonist
3552 PD 173212
Potent CaV2.2 blocker
1439 Ruthenium Red
Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
2945 SNX 482
Potent and selective CaV2.3 blocker

CaV2.x channels are high-voltage activated calcium channels that are insensitive to blockade by dihydropyridines. There are three members in this family, which all show high expression in the central and peripheral nervous systems, where they mediate neurotransmitter release and are critical to neurotransmission.

CaV2.1 channels (P/Q-type) may have a role in Alzheimer's disease, as amyloid-β oligomers are thought to directly regulate Ca2+ current through the channel. Mutations in the CaV2.1 α1-subunit have been linked to migraine headaches. Mutations in the CaV2.2 (N-type) α1-subunit have been associated with neuropsychiatric disorders including autism, bipolar disorder and schizophrenia. Selective blockers of CaV2.2 channels are used to treat chronic pain, via intrathecal injection into the spine. Few studies of CaV2.3 (R-type) channels have been reported to date.

External sources of pharmacological information for CaV2.x Channels :

    Literature for CaV2.x Channels

    Tocris offers the following scientific literature for CaV2.x Channels to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Ion Channel Product Listing

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    Neurotransmission

    Neurotransmission Product Guide

    A collection of over 250 products for neurotransmission research, the guide includes research tools for the study of:

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    Pain Research Product Guide

    A collection of over 250 products for pain research, the guide includes research tools for the study of:

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    Voltage-gated Calcium Channel Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Cav2.1 Human CACNA1A NM_000068 Q99793
    Mouse Cacna1a NM_007578 P97445
    Rat Cacna1a NM_012918 Q2YS39
    Cav2.2 Human CACNA1B NM_000718 Q00975
    Mouse Cacna1b NM_007579 O55017
    Rat Cacna1b NM_147141 Q9R1B6
    Cav2.3 Human CACNA1E NM_000721 Q15878
    Mouse Cacna1e NM_009782 Q61290
    Rat Cacna1e NM_019294 O35781