ω-Conotoxin GVIA

Pricing Availability Delivery Time Qty
Cat.No. 1085 - w-Conotoxin GVIA | Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridges: 1 - 16, 8 - 19, 15 - 26) | CAS No. 106375-28-4
Description: Ca2+ channel blocker (N-type)
Datasheet
Citations (12)
Literature

Biological Activity

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.

Technical Data

M. Wt 3037
Formula C120H182N38O43S6
Sequence CKSXGSSCSXTSYNCCRSCNXYTKRCY

(Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 106375-28-4
PubChem ID 90479753
InChI Key DRVGOMCWRXUORL-QPEMYEDGSA-N
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3037. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.65 mL 3.29 mL
5 mM 0.07 mL 0.33 mL 0.66 mL
10 mM 0.03 mL 0.16 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431 PMID: 2469160

Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392 PMID: 9300325

Connelly et al (2011) Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 667 160 PMID: 21575629

Sato et al (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 194 1292 PMID: 8394704


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View all Voltage-gated Calcium Channel (CaV) Blockers

Keywords: Ca2+ channel blockers N-type Calcium CaV Channels voltage-gated voltage-dependent omega-Conotoxin ω-conotoxin GVIA neurotoxins venoms Voltage-gated Calcium Channels

12 Citations for ω-Conotoxin GVIA

Citations are publications that use Tocris products. Selected citations for ω-Conotoxin GVIA include:

Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Front Cell Neurosci 11 e0154932 PMID: 27183222

Perissinotti et al (2015) Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Proc Natl Acad Sci U S A 8 444 PMID: 25610372

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Addict Biol 350 290 PMID: 24891452

Mahler et al (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. J Neurosci 19 49 PMID: 23017017

Szabó et al (2014) Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release. PLoS One 34 7958 PMID: 24899717

Schuwald et al (2013) Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. J Neurosci 8 e59998 PMID: 23637742

Medrihan et al (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nature 4 1512 PMID: 23443540

Kim and Alger (2010) Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci 13 592 PMID: 20348918

Grubb and Burrone (2010) Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. J Pharmacol Exp Ther 465 1070 PMID: 20543823

Chu et al (2009) Secretin as a neurohypophysial factor regulating body water homeostasis. PLoS One 106 15961 PMID: 19805236

Haeberle et al (2004) Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A 101 14503 PMID: 15448211


Do you know of a great paper that uses ω-Conotoxin GVIA from Tocris? If so please let us know.

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Literature in this Area

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Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for ω-Conotoxin GVIA

Protocols

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