Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 786.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.27 mL||6.36 mL||12.72 mL|
|5 mM||0.25 mL||1.27 mL||2.54 mL|
|10 mM||0.13 mL||0.64 mL||1.27 mL|
|50 mM||0.03 mL||0.13 mL||0.25 mL|
References are publications that support the products' biological activity.
Amann and Maggi (1991) Ruthenium red as a capsaicin antagonist. Life Sci. 49 849 PMID: 1715010
Bernardi et al (1984) Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 23 1645 PMID: 6202317
Szallasi and Blumberg (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 51 159 PMID: 10353985
Xu et al (1999) Ruthenium red modifies the cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 274 32680 PMID: 10551824
If you know of a relevant reference for Ruthenium Red, please let us know.
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Keywords: Ruthenium Red, supplier, inhibitors, inhibits, ryanodine-sensitive, Ca2+, release, mitochondrial, reuptake, Blockers, capsaicin-activated, cation, channels, Non-Selective, Vanillioid, Receptors, VR1, TRPV, Transient, Receptor, Potential, CaV, P-Type, N-Type, voltage-gated, voltage-dependent, Voltage-gated, Calcium, Channels, General, Calcium, Signaling, Agents, TRPV, Ryanodine, Receptors, Voltage-gated, Calcium, Channels, Tocris Bioscience
10 Citations for Ruthenium Red
Citations are publications that use Tocris products. Selected citations for Ruthenium Red include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 e2640 PMID: 28252652
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Proc Natl Acad Sci U S A 21 4852 PMID: 25944998
Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. Neuroreport 10 e0132884 PMID: 26222156
Jacques-Fricke et al (2006) Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. World J Gastroenterol 26 5656 PMID: 16723522
Russo et al (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides The Journal of Immunology 197 1353 PMID: 27385780
Moran et al (2004) Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J Neurophysiol 92 3266 PMID: 15295007
Albert et al (2012) TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol 107 3227 PMID: 22442563
Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. PLoS One 111 E5114 PMID: 25385580
Kaszás et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J Neurosci 340 152 PMID: 22005042
Nesuashvili et al (2013) Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007 PMID: 23444014
Do you know of a great paper that uses Ruthenium Red from Tocris? If so please let us know.
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.