Nefiracetam

Pricing Availability Delivery Time Qty
Cat.No. 2851 - Nefiracetam | C14H18N2O2 | CAS No. 77191-36-7
Description: Cognitive enhancer
Alternative Names: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.

Compound Libraries

Nefiracetam is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 246.3
Formula C14H18N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 77191-36-7
PubChem ID 71157
InChI Key NGHTXZCKLWZPGK-UHFFFAOYSA-N
Smiles O=C(NC2=C(C)C=CC=C2C)CN1C(CCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.63 100
ethanol 24.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 246.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Narahashi et al (2004) Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 27 1701 PMID: 15516710

Ueda et al (2004) The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 309 200 PMID: 14718588

Kitano et al (2005) Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46 1561 PMID: 16190926


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Keywords: Cognitive enhancer activates L/N-type Ca2+ channels potentiates NMDA currents Muscarinic Receptors Acetylcholine Nicotinic nAChR Calcium CaV Channels L-Type N-Type voltage-gated voltage-dependent Glutamate N-Methyl-D-Aspartate iGluR Ionotropic DM9384 DM 9384 Other Acetylcholine

Citations for Nefiracetam

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Literature in this Area

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Pathways for Nefiracetam

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