Pricing Availability   Qty
Description: Cognitive enhancer
Alternative Names: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Nefiracetam

Nefiracetam is a cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.

Technical Data for Nefiracetam

M. Wt 246.3
Formula C14H18N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 77191-36-7
PubChem ID 71157
Smiles O=C(NC2=C(C)C=CC=C2C)CN1C(CCC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nefiracetam

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.63 100
ethanol 24.63 100

Preparing Stock Solutions for Nefiracetam

The following data is based on the product molecular weight 246.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Nefiracetam

References are publications that support the biological activity of the product.

Narahashi et al (2004) Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 27 1701 PMID: 15516710

Ueda et al (2004) The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 309 200 PMID: 14718588

Kitano et al (2005) Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46 1561 PMID: 16190926

If you know of a relevant reference for Nefiracetam, please let us know.

Keywords: Nefiracetam, Nefiracetam supplier, Cognitive, enhancer, activates, L/N-type, Ca2+, channels, potentiates, NMDA, currents, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, DM9384, DM, 9384, Other, Cav1.x, Non-selective, Muscarinics, Cav2.x, 2851, Tocris Bioscience

Citations for Nefiracetam

Citations are publications that use Tocris products.

Currently there are no citations for Nefiracetam. Do you know of a great paper that uses Nefiracetam from Tocris? Please let us know.

Reviews for Nefiracetam

There are currently no reviews for this product. Be the first to review Nefiracetam and earn rewards!

Have you used Nefiracetam?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.