LY 310762 hydrochloride

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Cat.No. 3078 - LY 310762 hydrochloride | C24H27FN2O2.HCl | CAS No. 192927-92-7
Description: 5-HT1D-preferring antagonist
Chemical Name: 1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

5-HT1D-preferring receptor antagonist (EC50 = 31 nM). Displays no activity on 5-HT transport.

Licensing Information

Sold under license from Eli Lilly and company

Technical Data

M. Wt 430.94
Formula C24H27FN2O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 192927-92-7
PubChem ID 11957576
InChI Key BOCLFQZPFYNVFD-UHFFFAOYSA-N
Smiles CC(C1=CC=CC=C1N2CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)(C)C2=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.09 100
water 4.31 10

Preparing Stock Solutions

The following data is based on the product molecular weight 430.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.6 mL 23.21 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Pullar et al (2004) The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur.J.Pharmacol. 493 85 PMID: 15189767


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1 Citation for LY 310762 hydrochloride

Citations are publications that use Tocris products. Selected citations for LY 310762 hydrochloride include:

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Pain 352 53 PMID: 25332454


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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.