Cat. No. 4439

ISX 9 C11H10N2O2S [832115-62-5]

Price and Availability

For ISX 9 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

Biological Activity

Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067. PMID: 22413910.

Dioum et al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713. PMID: 22143803.

Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233. PMID: 21419563.

Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408. PMID: 18552832.

If you know of a relevant reference for ISX 9 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses ISX 9 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: ISX 9, supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Tocris Bioscience, Neural Stem Cells products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

divider line

Stem Cells Scientific Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

divider line

Bio-Techne Events


6th Annual Meeting GDR3545

November 8 - 10, 2017

Paris, France