Cat. No. 4439
Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxa
Biological ActivityNeurogenic agent. Mediates neuroD reporter gene induction via activation of Ca2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067. PMID: 22413910.
Dioum et al (2011) A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713. PMID: 22143803.
Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233. PMID: 21419563.
Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408. PMID: 18552832.
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Keywords: ISX 9, supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Tocris Bioscience, Stem Cell Differentiation products
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