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TB4439-RMU is an Ancillary Material Grade version of product ISX 9 (Cat. No. 4439). Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.
Find out more about our Ancillary Material Grade product range.
|Storage||Store at 2-8°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408 PMID: 18552832
Dioum et al (2011) A small molecule differentiation inducer increases Ins production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713 PMID: 22143803
Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233 PMID: 21419563
Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067 PMID: 22413910
If you know of a relevant reference for ISX 9, please let us know.
Keywords: ISX 9, ISX 9 supplier, ISX9, ancillary, material, grade, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Ancillary, Material, Grade, Small, Molecules, TB4439-RMU, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for ISX 9 include:
Pujol et al (2018) Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci 19 PMID: 30150605
Xie et al (2018) β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet 14 e1007846 PMID: 30557298
Koh et al (2015) Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One 10 e0138724 PMID: 26407349
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.