U 18666A

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Cat.No. 1638 - U 18666A | C25H41NO2.HCl | CAS No. 3039-71-2
Description: Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Datasheet
Citations
Literature

Biological Activity

Inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.

Technical Data

M. Wt 424.07
Formula C25H41NO2.HCl
Storage Desiccate at RT
CAS Number 3039-71-2
PubChem ID 92722
InChI Key KXNPVXPOPUZYGB-IOVMHBDKSA-N
Smiles [H][C@@]23CC=C1C[C@@H](OCCN(CC)CC)CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.76 100
ethanol 38.76 100
water 38.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 424.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.79 mL 23.58 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cenedella et al (1980) Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 29 2751 PMID: 6159896

Incardona et al (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 224 440 PMID: 10926779

Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 PMID: 2745416


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Keywords: inhibitors hedgehog Hh signaling inhibits cholesterol synthesis Signalling Hedgehog U18666A Hedgehog Signaling

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Literature in this Area

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