U 18666A

Discontinued Product

U 18666A (Cat. No. 1638) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Reviews (1)
Literature (4)

Biological Activity for U 18666A

U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.

Technical Data for U 18666A

M. Wt 424.07
Formula C25H41NO2.HCl
Storage Desiccate at RT
CAS Number 3039-71-2
PubChem ID 92722
Smiles [H][C@@]23CC=C1C[C@@H](OCCN(CC)CC)CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for U 18666A

References are publications that support the biological activity of the product.

Cenedella et al (1980) Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 29 2751 PMID: 6159896

Incardona et al (2000) Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 224 440 PMID: 10926779

Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 264 11796 PMID: 2745416

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Keywords: U 18666A, U 18666A supplier, inhibitors, hedgehog, Hh, signaling, inhibits, cholesterol, synthesis, Signalling, Hedgehog, U18666A, Signaling, 1638, Tocris Bioscience

Citations for U 18666A

Citations are publications that use Tocris products.

Currently there are no citations for U 18666A.

Reviews for U 18666A

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Cholesterol accumulation increased by U18666A treatment.
By ASHUTOSH SINGHAL on 01/05/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: HeLa

I used 2.5-10 ug/ml of U18666A to inhibit the cholesterol efflux in HeLa cells and it worked perfectly as I observed in U18666A treated HeLa cells accumulated cholesterol significantly. I used Filipin staining to image and quantitate the cholesterol levels.

I dissolved the U18666A in water and stored at -20C in aliquots.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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