You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued Product(R)-Shikonin (Cat. No. 6829) has been withdrawn from sale for commercial reasons.
Biological Activity for (R)-Shikonin
(R)-Shikonin is a PTEN and inflammasome inhibitor. Inhibits PTEN's phosphatase activity (IC50 = 2.7 μM) and NLRP3 activation. Also blocks TNF-α and NF-κB signaling. Attenuates HIV-1 replication at nanomolar concentrations. (R)-Shikonin suppresses glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2) (IC50 = 0.3 μM) and inhibits tumor proliferation. Induces necroptosis in MCF-7 and HEK293 cancer cell lines. (R)-Shikonin also displays anti-inflammatory activity in a mouse model of collagen-induced arthritis.
Technical Data for (R)-Shikonin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for (R)-Shikonin
References are publications that support the biological activity of the product.
McLoughlin et al (2018) The therapeutic potential of PTEN modulation: targeting strategies from gene to protein. Cell Chem.Biol. 25 19 PMID: 29153852
Nigorikawa et al (2006) A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Mol.Pharmacol. 70 1143 PMID: 16804092
Hafner-Bratkovic et al (2018) NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 9 5182 PMID: 30518920
Chen et al (2011) Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene 30 4297 PMID: 21516121
Han et al (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol. Cancer Ther. 6 1641 PMID: 17513612
Chen et al (2003) Shikonin, a Component of Chinese Herbal Medicine, Inhibits Chemokine Receptor Function and Suppresses Human Immunodeficiency Virus Type 1 Antimicrob. Agents Chemother. 47 2810 PMID: 12936978
Kim et al (2010) The efficacy of shikonin on cartilage protection in a mouse model of rheumatoid arthritis. Korean J.Physiol.Pharmacol. 14 199 PMID: 20827333
Zhao et al (2018) Shikonin inhibits tumor growth in mice by suppressing pyruvate kinase M2-mediated aerobic glycolysis. Sci.Rep. 8 14517 PMID: 30266938
View Related Products by Target
View Related Products by Product Action
Keywords: (R)-Shikonin, (R)-Shikonin supplier, PTEN, inhibitors, inhibits, inducers, necroptosis, anti-inflammatory, NLRP3, TNF-α, NF-κB, HIV-1, replication, pyruvate, kinase, M2, PKM2, NF-kappaB, TNF-alpha, alfa, Protein, Tyrosine, Phosphatases, Inflammasomes, NF-kB/IkB, Cytokines, Other, Kinases, Necroptosis, HIV, 6829, Tocris Bioscience
Citations for (R)-Shikonin
Citations are publications that use Tocris products.
Currently there are no citations for (R)-Shikonin.
Reviews for (R)-Shikonin
There are currently no reviews for this product. Be the first to review (R)-Shikonin and earn rewards!
Have you used (R)-Shikonin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.