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Mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 73.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||13.53 mL||67.67 mL||135.34 mL|
|5 mM||2.71 mL||13.53 mL||27.07 mL|
|10 mM||1.35 mL||6.77 mL||13.53 mL|
|50 mM||0.27 mL||1.35 mL||2.71 mL|
References are publications that support the biological activity of the product.
Lenox and Hahn (2000) Overview of the mechanism of action of Li in the brain: fifty-year update. J.Clin.Psychiatry 61 5 PMID: 10826655
Gould et al (2004) In vivo evidence in the brain for Li inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29 32 PMID: 12942141
If you know of a relevant reference for Lithium carbonate, please let us know.
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Keywords: Lithium carbonate, Lithium carbonate supplier, Mood, stabilizers, sodium, potassium, Na+/K+, ATPase, pumps, bipolar, Glycogen, Synthase, Kinase, 3, 4740, Tocris Bioscience
Citations for Lithium carbonate
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Currently there are no citations for Lithium carbonate. Do you know of a great paper that uses Lithium carbonate from Tocris? Please let us know.
Reviews for Lithium carbonate
Average Rating: 5 (Based on 1 Review.)
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Guinea pig ventricular cardiomyocytes were patched and stimulated at a 1 Hz frequency to record action potentials before and after Li2CO3 (10 and 30 µM). Li2CO3 significantly prolonged action potential duration at 20% and 90% repolarization levels.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.