Lithium carbonate

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Cat.No. 4740 - Lithium carbonate | Li2CO3 | CAS No. 554-13-2
Description: Mood stabilizer; inhibits GSK-3 in vivo
Chemical Name: Carbonic acid dilithium salt

Biological Activity

Mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.

Technical Data

M. Wt 73.89
Formula Li2CO3
Storage Store at RT
CAS Number 554-13-2
PubChem ID 11125
Smiles [Li+].[Li+].[O-]C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 7.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 73.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 13.53 mL 67.67 mL 135.34 mL
5 mM 2.71 mL 13.53 mL 27.07 mL
10 mM 1.35 mL 6.77 mL 13.53 mL
50 mM 0.27 mL 1.35 mL 2.71 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Lenox and Hahn (2000) Overview of the mechanism of action of lithium in the brain: fifty-year update. J.Clin.Psychiatry 61 5 PMID: 10826655

Gould et al (2004) In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29 32 PMID: 12942141

If you know of a relevant reference for Lithium carbonate, please let us know.

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Keywords: Mood stabilizers sodium potassium Na+/K+ ATPase pumps bipolar Glycogen Synthase Kinase 3

Citations for Lithium carbonate

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Pathways for Lithium carbonate


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