Lithium carbonate

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Cat.No. 4740 - Lithium carbonate | Li2CO3 | CAS No. 554-13-2
Description: Mood stabilizer; inhibits GSK-3 in vivo
Chemical Name: Carbonic acid dilithium salt
Reviews (1)

Biological Activity

Mood stabilizer; thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Effective in the treatment of bipolar disorder. Inhibits GSK-3 in vivo.

Technical Data

M. Wt 73.89
Formula Li2CO3
Storage Store at RT
CAS Number 554-13-2
PubChem ID 11125
Smiles [Li+].[Li+].[O-]C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 7.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 73.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 13.53 mL 67.67 mL 135.34 mL
5 mM 2.71 mL 13.53 mL 27.07 mL
10 mM 1.35 mL 6.77 mL 13.53 mL
50 mM 0.27 mL 1.35 mL 2.71 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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References are publications that support the biological activity of the product.

Lenox and Hahn (2000) Overview of the mechanism of action of Li in the brain: fifty-year update. J.Clin.Psychiatry 61 5 PMID: 10826655

Gould et al (2004) In vivo evidence in the brain for Li inhibition of glycogen synthase kinase-3. Neuropsychopharmacology 29 32 PMID: 12942141

If you know of a relevant reference for Lithium carbonate, please let us know.

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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: Lithium carbonate, Lithium carbonate supplier, Mood, stabilizers, sodium, potassium, Na+/K+, ATPase, pumps, bipolar, Glycogen, Synthase, Kinase, 3, 4740, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Lithium carbonate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

Citations for Lithium carbonate

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Li2CO3 prolongs cardiac action potential duration.
By Chintan Koyani on 10/23/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Ventricular cardiomyocytes

Guinea pig ventricular cardiomyocytes were patched and stimulated at a 1 Hz frequency to record action potentials before and after Li2CO3 (10 and 30 µM). Li2CO3 significantly prolonged action potential duration at 20% and 90% repolarization levels.

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