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Bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Bokoch et al (1983) Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 258 2072 PMID: 6296122
Barbieri and Cortina (1988) ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 56 1934 PMID: 3135265
Casey et al (1989) G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa. Biochemistry 28 611 PMID: 2496748
If you know of a relevant reference for Pertussis Toxin, please let us know.
Keywords: Pertussis Toxin, Pertussis Toxin supplier, Catalyzes, ADP-ribosylation, G-Protein, Heterotrimeric, Gi, Go, Gt, toxin, G-protein, GTPases, 3097, Tocris Bioscience
19 Citations for Pertussis Toxin
Citations are publications that use Tocris products. Selected citations for Pertussis Toxin include:
O'Neill & Sylantyev (2018) Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C. Exp Biol Med (Maywood) 243 1046 PMID: 30205722
Cheng et al (2012) Cytoskeletal role in protection of the failing heart by β-adrenergic blockade. Proc Natl Acad Sci U S A 302 H675 PMID: 22081703
Wydeven et al (2012) Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A 109 21492 PMID: 23236146
Rimmerman et al (2013) Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis 4 e949 PMID: 24309936
Jones et al (2015) Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun 3 28 PMID: 25990016
Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600
Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718
Zhao et al (2018) Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and Ca2. Molecules 23 PMID: 30424024
Yuan et al (2016) Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Am J Physiol Heart Circ Physiol 7 11024 PMID: 26996322
Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Dis Model Mech 112 6497 PMID: 25941381
Sim et al (2015) A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocy. green dye. Int J Cancer 8 1479 PMID: 26398933
Choi et al (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. J Neurosci 136 E219 PMID: 25137150
Boldison et al (2014) Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. J Immunol 192 4541 PMID: 24740509
Butschkau et al (2014) Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS One 9 e113554 PMID: 25474349
Park et al (2011) Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. Neuron 31 18433 PMID: 22171045
Li et al (2017) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics 7 4671 PMID: 29187895
Crawford et al (2015) The role of lipoprotein-associated phospholipase A2 in a murine model of experimental autoimmune uveoretinitis. PLoS One 10 e0122093 PMID: 25874928
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
Nagaraja et al (1999) Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation. Nat Commun 127 1099 PMID: 10455254
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Reviews for Pertussis Toxin
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Pertussis toxin (PeTX) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of G-protein signalling with PeTX GABA-A receptor antagonists SR 95531 and Picrotoxin generate smaller impact on RMS noise than after block of PKA with PKI.
MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. Pertussis Toxin inhibited COX-2 expression induced by LPA.
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