Pertussis Toxin

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Cat.No. 3097 - Pertussis Toxin | CAS No. 70323-44-3
Description: Catalyzes ADP-ribosylation of Gi, Go and Gt
Citations (12)

Biological Activity

Bacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.

Technical Data

Storage Store at +4°C
CAS Number 70323-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Bokoch et al (1983) Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 258 2072 PMID: 6296122

Barbieri and Cortina (1988) ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 56 1934 PMID: 3135265

Casey et al (1989) G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa. Biochemistry 28 611 PMID: 2496748

If you know of a relevant reference for Pertussis Toxin, please let us know.

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Keywords: Pertussis Toxin, supplier, Catalyzes, ADP-ribosylation, G-Protein, Heterotrimeric, Gi, Go, Gt, toxin, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience

12 Citations for Pertussis Toxin

Citations are publications that use Tocris products. Selected citations for Pertussis Toxin include:

Jones et al (2015) Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica. Acta Neuropathol Commun 3 28 PMID: 25990016

Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Dis Model Mech 112 6497 PMID: 25941381

Sim et al (2015) A simple method for in vivo labelling of infiltrating leukocytes in the mouse retina using indocyanine green dye. Int J Cancer 8 1479 PMID: 26398933

Choi et al (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. J Neurosci 136 E219 PMID: 25137150

Cheng et al (2012) Cytoskeletal role in protection of the failing heart by β-adrenergic blockade. Proc Natl Acad Sci U S A 302 H675 PMID: 22081703

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Park et al (2011) Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. Neuron 31 18433 PMID: 22171045

Yuan et al (2016) Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Am J Physiol Heart Circ Physiol 7 11024 PMID: 26996322

Boldison et al (2014) Tissue-resident exhausted effector memory CD8+ T cells accumulate in the retina during chronic experimental autoimmune uveoretinitis. J Immunol 192 4541 PMID: 24740509

Butschkau et al (2014) Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS One 9 e113554 PMID: 25474349

Nagaraja et al (1999) Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic β2-adrenoceptor activation. Nat Commun 127 1099 PMID: 10455254

Wydeven et al (2012) Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. Proc Natl Acad Sci U S A 109 21492 PMID: 23236146

Do you know of a great paper that uses Pertussis Toxin from Tocris? If so please let us know.

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