(S)-(+)-Ketamine hydrochloride

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Description: NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Chemical Name: (S)-(+)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for (S)-(+)-Ketamine hydrochloride

(S)-(+)-Ketamine hydrochloride is a NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.

Racemate also available.

Technical Data for (S)-(+)-Ketamine hydrochloride

M. Wt 274.19
Formula C13H16ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33643-47-9
PubChem ID 44632368
Smiles O=C1[C@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (S)-(+)-Ketamine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 27.42 100
DMSO 27.42 100

Preparing Stock Solutions for (S)-(+)-Ketamine hydrochloride

The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets for (S)-(+)-Ketamine hydrochloride

Certificate of Analysis / Product Datasheet
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References for (S)-(+)-Ketamine hydrochloride

References are publications that support the biological activity of the product.

Ryder et al (1978) Comparative pharmacology of the optical isomers of KA in mice. Eur.J.Pharmacol. 49 15 PMID: 658124

Proescholdt et al (2001) Neuroprotection of S(+) KA isomer in global forebrain ischemia. Brain Res. 904 245 PMID: 11406122

Benrath et al (2005) Low dose of S(+)-KA prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 95 518 PMID: 16113037

If you know of a relevant reference for (S)-(+)-Ketamine hydrochloride, please let us know.

Keywords: (S)-(+)-Ketamine hydrochloride, (S)-(+)-Ketamine hydrochloride supplier, nmda, nmdar, antagonists, NMDA, Receptors, Ketamine, and, Metabolites, 4379, Tocris Bioscience

Citations for (S)-(+)-Ketamine hydrochloride

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Literature in this Area

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