NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.
Racemate also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.65 mL||18.24 mL||36.47 mL|
|5 mM||0.73 mL||3.65 mL||7.29 mL|
|10 mM||0.36 mL||1.82 mL||3.65 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References are publications that support the biological activity of the product.
Ryder et al (1978) Comparative pharmacology of the optical isomers of ketamine in mice. Eur.J.Pharmacol. 49 15 PMID: 658124
Proescholdt et al (2001) Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res. 904 245 PMID: 11406122
Benrath et al (2005) Low dose of S(+)-ketamine prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 95 518 PMID: 16113037
If you know of a relevant reference for (S)-(+)-Ketamine hydrochloride, please let us know.
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.