(S)-(+)-Ketamine hydrochloride

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Cat.No. 4379 - (S)-(+)-Ketamine hydrochloride | C13H16ClNO.HCl | CAS No. 33643-47-9
Description: NMDA receptor antagonist; enantiomer of ketamine hydrochloride (Cat. No. 3131); neuroprotective
Chemical Name: (S)-(+)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

NMDA receptor antagonist. Displays neuroprotective efficacy in vitro.

Racemate also available.

Technical Data

M. Wt 274.19
Formula C13H16ClNO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 33643-47-9
PubChem ID 44632368
InChI Key VCMGMSHEPQENPE-ZOWNYOTGSA-N
Smiles O=C1[C@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.42 100
DMSO 27.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 274.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.65 mL 18.24 mL 36.47 mL
5 mM 0.73 mL 3.65 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.65 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ryder et al (1978) Comparative pharmacology of the optical isomers of ketamine in mice. Eur.J.Pharmacol. 49 15 PMID: 658124

Proescholdt et al (2001) Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res. 904 245 PMID: 11406122

Benrath et al (2005) Low dose of S(+)-ketamine prevents long-term potentiation in pain pathways under strong opioid analgesia in the rat spinal cord in vivo. Br.J.Anaesth. 95 518 PMID: 16113037


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Keywords: (S)-(+)-Ketamine hydrochloride, (S)-(+)-Ketamine hydrochloride supplier, nmda, nmdar, antagonists, NMDA, Receptors, Ketamine, and, Metabolites, 4379, Tocris Bioscience

Citations for (S)-(+)-Ketamine hydrochloride

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