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Cat.No. 5513 - Isotretinoin | C20H28O2 | CAS No. 4759-48-2
Description: Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation
Alternative Names: 13-cis-retinoic acid, Accutane
Chemical Name: 13-cis-Retinoic acid
Purity: ≥99% (HPLC)

Biological Activity

Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.

Technical Data

M. Wt 300.44
Formula C20H28O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 4759-48-2
PubChem ID 5282379
Smiles C/C(/C=C/C=C(C)/C=C/C1=C(C)CCCC(C)1C)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.04 100
ethanol 6.01 20

Preparing Stock Solutions

The following data is based on the product molecular weight 300.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.64 mL 33.28 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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References are publications that support the products' biological activity.

Diamandis et al (2007) Chemical genetics reveals a complex functional ground state of neural stem cells. Nat.Chem.Biol. 3 268 PMID: 17417631

Blaner et al (2001) Cellular metabolism and actions of 13-cis-retinoic acid. J.Am.Acad.Dermatol. 45 S129 PMID: 11606944

Sonawane et al (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br.J.Pharmacol. 171 5330 PMID: 25039756

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