EC 23

Pricing Availability   Qty
Description: Synthetic retinoid; induces differentiation of stem cells
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
Purity: ≥99% (HPLC)
Citations (2)
Literature (1)

Biological Activity for EC 23

EC 23 is a photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model Potently induces neural differentiation in human pluripotent embryonic stem cells.

Licensing Information

Sold under license from Reinnervate Limited, patent pending

Compound Libraries for EC 23

EC 23 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for EC 23

M. Wt 332.44
Formula C23H24O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 104561-41-3
PubChem ID 10314719
Smiles CC1(C)C2=C(C=CC(C#CC3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EC 23

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.24 100
ethanol 1.66 5

Preparing Stock Solutions for EC 23

The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets for EC 23

Certificate of Analysis / Product Datasheet
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References for EC 23

References are publications that support the biological activity of the product.

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150

Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430 PMID: 19821467

Maltman et al (2009) Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 5 458 PMID: 19381361

If you know of a relevant reference for EC 23, please let us know.

Keywords: EC 23, EC 23 supplier, retinoids, synthetic, stem, cells, induces, differentiation, ATRA, retinoic, acid, receptors, agonists, EC23, Retinoic, Acid, Receptors, Retinal, Stem, Cells, ESCs, and, iPSC, 4011, Tocris Bioscience

2 Citations for EC 23

Citations are publications that use Tocris products. Selected citations for EC 23 include:

Santos-Ferreira et al (2019) Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry. Cytometry A PMID: 31107590

Ying et al (2020) Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Front Cell Infect Microbiol 10 278 PMID: 32637364

Do you know of a great paper that uses EC 23 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.