EC 23

Pricing Availability Delivery Time Qty
Cat.No. 4011 - EC 23 | C23H24O2 | CAS No. 104561-41-3
Description: Synthetic retinoid; induces differentiation of stem cells
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.

Licensing Information

Sold under license from Reinnervate Limited, patent pending

Compound Libraries

EC 23 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 332.44
Formula C23H24O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 104561-41-3
PubChem ID 10314719
InChI Key OQVLOWLEEHYBJH-UHFFFAOYSA-N
Smiles CC1(C)C2=C(C=CC(C#CC3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.24 100
ethanol 3.32 10

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150

Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430 PMID: 19821467

Maltman et al (2009) Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 5 458 PMID: 19381361


If you know of a relevant reference for EC 23, please let us know.

Keywords: retinoids synthetic stem cells induces differentiation ATRA retinoic acid receptors agonists EC23 Retinoic Acid Receptors

Citations for EC 23

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Reviews

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Literature in this Area

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Retinoid Receptors Scientific Review

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Pathways for EC 23

Protocols

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