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Submit ReviewCHIR 99021 trihydrochloride
Description: Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.
Technical Data
| M. Wt | 574.72 |
| Formula | C22H18Cl2N8.3HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1782235-14-6 |
| PubChem ID | 78243722 |
| InChI Key | DSFVSCNMMZRCIA-UHFFFAOYSA-N |
| Smiles | ClC(C=C3Cl)=CC=C3C1=NC(NCCNC4=CC=C(C#N)C=N4)=NC=C1C2=NC(C)=CN2.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.37 | 25 | |
| DMSO | 28.74 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 574.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.48 mL | 17.4 mL | 34.8 mL |
| 2.5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 25 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Pan et al (2011) AKT kinase activity is required for Li to modulate mood-related behaviors in mice. Neuropsychopharmacology 36 1397 PMID: 21389981
Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497
Ye et al (2012) Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 7 e35892 PMID: 22540008
If you know of a relevant reference for CHIR 99021 trihydrochloride, please let us know.
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4 Citations for CHIR 99021 trihydrochloride
Citations are publications that use Tocris products. Selected citations for CHIR 99021 trihydrochloride include:
Modic et al (2019) Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition. Mol Cell 74 951 PMID: 31047794
Ward and Gilad (2019) A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. Elife 8 PMID: 30958265
Montefiori et al (2018) A promoter interaction map for cardiovascular disease genetics. Elife 7 PMID: 29988018
Judson et al (2018) Inhibition of methyltransferase Setd7 allows in vitro expansion of myogenic stem cells with improved therapetic potential. Cell Stem Cell 22 177 PMID: 29395054
Do you know of a great paper that uses CHIR 99021 trihydrochloride from Tocris? Please let us know.
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