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Submit ReviewChicago Sky Blue 6B
Description: Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Biological Activity
Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.
Technical Data
| M. Wt | 992.79 |
| Formula | C34H24N6Na4O16S4 |
| Storage | Store at RT |
| CAS Number | 2610-05-1 |
| PubChem ID | 102063628 |
| InChI Key | BPHHNXJPFPEJOF-UHFFFAOYSA-J |
| Smiles | [Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96 PMID: 7790899
Fonnum et al (1994) Inhibitors of amino acid uptake into vesicles. J.Neurochem. 63 Suppl. 1 S49A
Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653 PMID: 22782901
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Keywords: Chicago Sky Blue 6B, Chicago Sky Blue 6B supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, Cytokines, Labels, and, Stains, 0846, Tocris Bioscience
1 Citation for Chicago Sky Blue 6B
Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:
Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653 PMID: 22782901
Do you know of a great paper that uses Chicago Sky Blue 6B from Tocris? Please let us know.
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