Chicago Sky Blue 6B

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Cat.No. 0846 - Chicago Sky Blue 6B | C34H24N6Na4O16S4 | CAS No. 2610-05-1
Description: Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.

Technical Data

M. Wt 992.79
Formula C34H24N6Na4O16S4
Storage Store at RT
CAS Number 2610-05-1
PubChem ID 102063628
InChI Key BPHHNXJPFPEJOF-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96 PMID: 7790899

Fonnum et al (1994) Inhibitors of amino acid uptake into vesicles. J.Neurochem. 63 Suppl. 1 S49A

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653 PMID: 22782901


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Keywords: Chicago Sky Blue 6B, Chicago Sky Blue 6B supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, Cytokines, Labels, and, Stains, 0846, Tocris Bioscience

1 Citation for Chicago Sky Blue 6B

Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653 PMID: 22782901


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