Chicago Sky Blue 6B

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Cat.No. 0846 - Chicago Sky Blue 6B | C34H24N6Na4O16S4 | CAS No. 2610-05-1
Description: Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Datasheet
Citations (1)
Literature

Biological Activity

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.

Technical Data

M. Wt 992.79
Formula C34H24N6Na4O16S4
Storage Store at RT
CAS Number 2610-05-1
PubChem ID 102063628
InChI Key BPHHNXJPFPEJOF-UHFFFAOYSA-J
Smiles [Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 992.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.01 mL 5.04 mL 10.07 mL
5 mM 0.2 mL 1.01 mL 2.01 mL
10 mM 0.1 mL 0.5 mL 1.01 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96 PMID: 7790899

Fonnum et al (1994) Inhibitors of amino acid uptake into vesicles. J.Neurochem. 63 Suppl. 1 S49A PMID:

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653 PMID: 22782901


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Keywords: Chicago Sky Blue 6B, supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, Glutamate, Transporters, Tocris Bioscience

1 Citation for Chicago Sky Blue 6B

Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653 PMID: 22782901


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