Chicago Sky Blue 6B

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Description: Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name: 6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Citations (1)
Literature (1)

Biological Activity for Chicago Sky Blue 6B

Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity. Also dye used as counterstain in histochemistry.

Technical Data for Chicago Sky Blue 6B

M. Wt 992.79
Formula C34H24N6Na4O16S4
Storage Store at RT
CAS Number 2610-05-1
PubChem ID 102063628
Smiles [Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Chicago Sky Blue 6B

Solvent Max Conc. mg/mL Max Conc. mM
water 99.28 100

Preparing Stock Solutions for Chicago Sky Blue 6B

The following data is based on the product molecular weight 992.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.01 mL 5.04 mL 10.07 mL
5 mM 0.2 mL 1.01 mL 2.01 mL
10 mM 0.1 mL 0.5 mL 1.01 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets for Chicago Sky Blue 6B

Certificate of Analysis / Product Datasheet
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References for Chicago Sky Blue 6B

References are publications that support the biological activity of the product.

Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96 PMID: 7790899

Fonnum et al (1994) Inhibitors of amino acid uptake into vesicles. J.Neurochem. 63 Suppl. 1 S49A

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653 PMID: 22782901

If you know of a relevant reference for Chicago Sky Blue 6B, please let us know.

Keywords: Chicago Sky Blue 6B, Chicago Sky Blue 6B supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, dye, counterstain, Cytokines, Labels, and, Stains, Fluorescent, Transporter, Probes, 0846, Tocris Bioscience

1 Citation for Chicago Sky Blue 6B

Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:

Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653 PMID: 22782901

Do you know of a great paper that uses Chicago Sky Blue 6B from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

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