Chicago Sky Blue 6B
Potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM); inhibits MIF proinflammatory activity.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 992.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.01 mL||5.04 mL||10.07 mL|
|5 mM||0.2 mL||1.01 mL||2.01 mL|
|10 mM||0.1 mL||0.5 mL||1.01 mL|
|50 mM||0.02 mL||0.1 mL||0.2 mL|
References are publications that support the products' biological activity.
Roseth et al (1995) Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 65 96 PMID: 7790899
Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 287 30653 PMID: 22782901
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Keywords: Chicago Sky Blue 6B, supplier, Potent, inhibitors, inhibits, L-glutamate, reuptake, synaptic, vesicles, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, Blue6B, Glutamate, Transporters, Cytokines, Glutamate, Transporters, Tocris Bioscience
1 Citation for Chicago Sky Blue 6B
Citations are publications that use Tocris products. Selected citations for Chicago Sky Blue 6B include:
Bai et al (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 287 30653 PMID: 22782901
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