BAY 293

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Cat.No. 6857 - BAY 293 | C25H28N4O2S | CAS No. 2244904-70-7
Description: Potent KRas/SOS1 interaction inhibitor
Chemical Name: (R)-6,7-Dimethoxy-2-methyl-N-[1-[4-[2-[(methylamino)methyl]phenyl]thiophene-2-yl]ethyl]quinazolin-4-amine
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Potent KRas/son of sevenless 1 (SOS1) interaction inhibitor (IC50 = 21 nM); active R-enantiomer. Downregulates active RAS in tumor cells. Inhibits RAS-RAF-MEK-ERK pathway. Exhibits synergistic effects with KRASG12C inhibitor ARS-853.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 293 probe summary on the SGC website.

Technical Data

M. Wt 448.59
Formula C25H28N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2244904-70-7
Smiles CNCC1=C(C=CC=C1)C1=CSC(=C1)[C@@H](C)NC1=NC(C)=NC2=C1C=C(OC)C(OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.86 100
ethanol 44.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 448.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.29 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References are publications that support the biological activity of the product.

Hillig et al (2019) Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc.Natl.Acad.Sci.USA. 116 2551 PMID: 30683722

If you know of a relevant reference for BAY 293, please let us know.

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Literature in this Area

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