AR-A 014418

Pricing Availability   Qty
Description: Selective GSK-3 inhibitor
Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Purity: ≥99% (HPLC)
Citations (4)
Literature (4)
Pathways (1)

Biological Activity for AR-A 014418

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AR-A 014418

AR-A 014418 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AR-A 014418

M. Wt 308.31
Formula C12H12N4O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 487021-52-3
PubChem ID 448014
Smiles O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AR-A 014418

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.83 100
ethanol 1.54 5

Preparing Stock Solutions for AR-A 014418

The following data is based on the product molecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References for AR-A 014418

References are publications that support the biological activity of the product.

Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251 PMID: 12566926

Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937 PMID: 12928438

Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387 PMID: 15315719

If you know of a relevant reference for AR-A 014418, please let us know.

View Related Products by Product Action

View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: AR-A 014418, AR-A 014418 supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3966, Tocris Bioscience

4 Citations for AR-A 014418

Citations are publications that use Tocris products. Selected citations for AR-A 014418 include:

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Tuberc Respir Dis (Seoul) 14 417 PMID: 25616418

Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475 PMID: 25764078

Chen et al (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci 32 13439 PMID: 23015435

Ling et al (2019) Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site. J Neuroinflammation 16 275 PMID: 31882005

Do you know of a great paper that uses AR-A 014418 from Tocris? Please let us know.

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Literature in this Area

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Pathways for AR-A 014418

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