AR-A 014418

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Cat.No. 3966 - AR-A 014418 | C12H12N4O4S | CAS No. 487021-52-3
Description: Selective GSK-3 inhibitor
Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

AR-A 014418 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 308.31
Formula C12H12N4O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 487021-52-3
PubChem ID 448014
InChI Key YAEMHJKFIIIULI-UHFFFAOYSA-N
Smiles O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.83 100
ethanol 1.54 5

Preparing Stock Solutions

The following data is based on the product molecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References

References are publications that support the biological activity of the product.

Bhat and Budd (2002) GSK3β signalling: casting a wide net in Alzheimer's disease. Neurosignals 11 251 PMID: 12566926

Bhat et al (2003) Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J.Biol.Chem. 278 45937 PMID: 12928438

Gould et al (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int.J.Neuropsychopharmacol. 7 387 PMID: 15315719


If you know of a relevant reference for AR-A 014418, please let us know.

View Related Products by Product Action

View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: AR-A 014418, AR-A 014418 supplier, ARA014418, glycogen, synthase, kinase, 3, GSK-3, GSK3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3966, Tocris Bioscience

3 Citations for AR-A 014418

Citations are publications that use Tocris products. Selected citations for AR-A 014418 include:

Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Tuberc Respir Dis (Seoul) 14 417 PMID: 25616418

Cuesto et al (2015) GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons. PLoS One 10 e0118475 PMID: 25764078

Chen et al (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci 32 13439 PMID: 23015435


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Literature in this Area

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