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Description: High affinity proteasome inhibitor
Chemical Name: B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Bortezomib

Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).

Compound Libraries for Bortezomib

Bortezomib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Bortezomib

M. Wt 384.24
Formula C19H25BN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 179324-69-7
PubChem ID 387447
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)B(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bortezomib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50 131
ethanol 10 27

Preparing Stock Solutions for Bortezomib

The following data is based on the product molecular weight 384.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1.31 mM 1.99 mL 9.93 mL 19.87 mL
6.55 mM 0.4 mL 1.99 mL 3.97 mL
13.1 mM 0.2 mL 0.99 mL 1.99 mL
65.5 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Dilution Calculator

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References for Bortezomib

References are publications that support the biological activity of the product.

Teicher et al (1999) The proteasome inhibitor PS-341 in cancer therapy. Clin.Cancer Res. 5 2638 PMID: 10499643

Hideshima et al (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61 3071 PMID: 11306489

If you know of a relevant reference for Bortezomib, please let us know.

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Keywords: Bortezomib, Bortezomib supplier, PS341, proteasome, inhibitor, multiple, myeloma, high, affinity, Proteasome, 7282, Tocris Bioscience

2 Citations for Bortezomib

Citations are publications that use Tocris products. Selected citations for Bortezomib include:

Vimla et al (2021) CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation. Cancers (Basel) 13 PMID: 34439093

Tomo et al (2023) ATP Consumption Is Coupled with Endocytosis in Exudated Neutrophils. Int J Mol Sci 24 PMID: 37240384

Do you know of a great paper that uses Bortezomib from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia