Bortezomib

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Cat.No. 7282 - Bortezomib | C19H25BN4O4 | CAS No. 179324-69-7
Description: High affinity proteasome inhibitor
Chemical Name: B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Bortezomib

Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).

Technical Data for Bortezomib

M. Wt 384.24
Formula C19H25BN4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 179324-69-7
PubChem ID 387447
InChI Key GXJABQQUPOEUTA-RDJZCZTQSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)B(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Bortezomib

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50 131
ethanol 10 27

Preparing Stock Solutions for Bortezomib

The following data is based on the product molecular weight 384.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1.31 mM 1.99 mL 9.93 mL 19.87 mL
6.55 mM 0.4 mL 1.99 mL 3.97 mL
13.1 mM 0.2 mL 0.99 mL 1.99 mL
65.5 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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References for Bortezomib

References are publications that support the biological activity of the product.

Teicher et al (1999) The proteasome inhibitor PS-341 in cancer therapy. Clin.Cancer Res. 5 2638 PMID: 10499643

Hideshima et al (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61 3071 PMID: 11306489


If you know of a relevant reference for Bortezomib, please let us know.

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Keywords: Bortezomib, Bortezomib supplier, PS341, proteasome, inhibitor, multiple, myeloma, high, affinity, Proteasome, 7282, Tocris Bioscience

Citations for Bortezomib

Citations are publications that use Tocris products.

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Literature in this Area

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