Syk Kinase

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2471 ER 27319 maleate
Selective Syk kinase inhibitor
5592 LCB 03-0110 dihydrochloride
Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2
2877 MNS
Selective inhibitor of Syk and Src
5711 Nilvadipine
Syk kinase inhibitor; inhibits Aβ production
6012 OXSI 2
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
1554 Piceatannol
Syk and p56lck kinase inhibitor

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

Literature for Syk Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Syk Kinase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Human SYK NR_024155 P43405
Mouse Syk NM_011518 P48025
Rat Syk NM_012758 Q63614