Syk Kinase

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2471 ER 27319 maleate
Selective Syk kinase inhibitor
6362 GSK 143
Syk inhibitor
5592 LCB 03-0110 dihydrochloride
Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2
2877 MNS
Selective inhibitor of Syk and Src
5711 Nilvadipine
Syk kinase inhibitor; inhibits Aβ production
6012 OXSI 2
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
1554 Piceatannol
Syk and p56lck kinase inhibitor

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

External sources of pharmacological information for Syk Kinase :

    Literature for Syk Kinase

    Tocris offers the following scientific literature for Syk Kinase to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

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    Syk Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Human SYK NR_024155 P43405
    Mouse Syk NM_011518 P48025
    Rat Syk NM_012758 Q63614