Home / Pharmacology / Enzymes / Kinases / Syk Kinase

Syk Kinase

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Products
Background
Gene Data

Syk Kinase Inhibitors
Cat. No. Product Name / Activity
2471 ER 27319 maleate
Selective Syk kinase inhibitor
6362 GSK 143
Syk inhibitor
5592 LCB 03-0110 dihydrochloride
Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

External sources of pharmacological information for Syk Kinase :

    Syk Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Human SYK NR_024155 P43405
    Mouse Syk NM_011518 P48025
    Rat Syk NM_012758 Q63614