Syk Kinase

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
2471 ER 27319 maleate
Selective Syk kinase inhibitor
5592 LCB 03-0110 dihydrochloride
Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2
2877 MNS
Selective inhibitor of Syk and Src
5711 Nilvadipine
Syk kinase inhibitor; inhibits Aβ production
6012 OXSI 2
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes
1554 Piceatannol
Syk and p56lck kinase inhibitor

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

Literature for Syk Kinase

Tocris offers the following scientific literature for Syk Kinase to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
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  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Syk Kinase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Human SYK NR_024155 P43405
Mouse Syk NM_011518 P48025
Rat Syk NM_012758 Q63614