Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.
Syk Kinase Inhibitors |
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Cat. No. | Product Name / Activity |
2471 | ER 27319 maleate |
Selective Syk kinase inhibitor | |
6362 | GSK 143 |
Syk inhibitor | |
5592 | LCB 03-0110 dihydrochloride |
Potent Syk kinase inhibitor; also inhibits BTK, c-Src and DDR2 | |
1554 | Piceatannol |
Syk and p56lck kinase inhibitor |
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.
Tocris offers the following scientific literature for Syk Kinase to showcase our products. We invite you to request* your copy today!
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