SLM 6031434 hydrochloride
Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.
Sold with the permission of the University of Virginia Patent Foundation
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 489.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.04 mL||10.2 mL||20.41 mL|
|5 mM||0.41 mL||2.04 mL||4.08 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the biological activity of the product.
Kharel et al (2015) Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 355 23 PMID: 26243740
If you know of a relevant reference for SLM 6031434 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: SLM 6031434 hydrochloride, SLM 6031434 hydrochloride supplier, SLM6031434, HCl, sphingosine, kinase, 2, Sphk2, inhibitors, inhibits, S1P, Sphingosine, Kinase, 6281, Tocris Bioscience
Citations for SLM 6031434 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for SLM 6031434 hydrochloride. Do you know of a great paper that uses SLM 6031434 hydrochloride from Tocris? Please let us know.
Reviews for SLM 6031434 hydrochloride
There are currently no reviews for this product. Be the first to review SLM 6031434 hydrochloride and earn rewards!
Have you used SLM 6031434 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.