SLM 6031434 hydrochloride

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Description: Selective sphingosine kinase 2 (Sphk2) inhibitor
Chemical Name: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Compound Libraries for SLM 6031434 hydrochloride

SLM 6031434 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SLM 6031434 hydrochloride

M. Wt 489.96
Formula C22H30F3N5O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1897379-34-8
PubChem ID 134812833
Smiles CCCCCCCCOC1=C(C(F)(F)F)C=C(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SLM 6031434 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 9.8 20
DMSO 49 100

Preparing Stock Solutions for SLM 6031434 hydrochloride

The following data is based on the product molecular weight 489.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.2 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets for SLM 6031434 hydrochloride

References for SLM 6031434 hydrochloride

References are publications that support the biological activity of the product.

Kharel et al (2015) Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 355 23 PMID: 26243740

Schwalm et al (2021) Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 79 PMID: 33301900

If you know of a relevant reference for SLM 6031434 hydrochloride, please let us know.

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Citations for SLM 6031434 hydrochloride

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