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SLM 6031434 hydrochloride
Biological Activity for SLM 6031434 hydrochloride
SLM 6031434 hydrochloride is a Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.
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Compound Libraries for SLM 6031434 hydrochloride
Technical Data for SLM 6031434 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SLM 6031434 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SLM 6031434 hydrochloride
The following data is based on the product molecular weight 489.96. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.04 mL||10.2 mL||20.41 mL|
|5 mM||0.41 mL||2.04 mL||4.08 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
Product Datasheets for SLM 6031434 hydrochloride
References for SLM 6031434 hydrochloride
References are publications that support the biological activity of the product.
Kharel et al (2015) Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 355 23 PMID: 26243740
Schwalm et al (2021) Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis. Cell Signal. 79 PMID: 33301900
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Citations for SLM 6031434 hydrochloride
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Literature in this Area
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