SLM 6031434 hydrochloride

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Cat.No. 6281 - SLM 6031434 hydrochloride | C22H30F3N5O2.HCl | CAS No. 1897379-34-8
Description: Selective sphingosine kinase 2 (Sphk2) inhibitor
Chemical Name: (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Sphk2 inhibitor (Ki = 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cells in vitro and increases blood levels of S1P in wild-type mice.

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Technical Data

M. Wt 489.96
Formula C22H30F3N5O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1897379-34-8
Smiles CCCCCCCCOC1=C(C(F)(F)F)C=C(C2=NOC([C@@H]3CCCN3C(N)=N)=N2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.8 20
DMSO 49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 489.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.2 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References

References are publications that support the biological activity of the product.

Kharel et al (2015) Sphingosine kinase 2 inhibition and blood sphingosine 1-phosphate levels. J.Pharmacol.Exp.Ther. 355 23 PMID: 26243740


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Citations for SLM 6031434 hydrochloride

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