IWP L6

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Cat.No. 4992 - IWP L6 | C25H20N4O2S2 | CAS No. 1427782-89-5
Description: Potent PORCN inhibitor
Chemical Name: N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

Technical Data

M. Wt 472.58
Formula C25H20N4O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1427782-89-5
PubChem ID 71601111
InChI Key QESQGTFWEQMCMH-UHFFFAOYSA-N
Smiles O=C1C3=C(CCS3)N=C(SCC(NC4=NC=C(C5=CC=CC=C5)C=C4)=O)N1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 472.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2013) The development of highly potent inhibitors for Porcupine. J.Med.Chem. 56 2700 PMID: 23477365


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Keywords: IWP L6, IWP L6 supplier, IWPL6, MBOAT, membrane-bound, O-acyltransferases, inhibitors, inhibits, porcupine, porcn, Wnt, PORCN, 4992, Tocris Bioscience

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