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Description: Potent PORCN inhibitor
Chemical Name: N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
Purity: ≥98% (HPLC)

Biological Activity for IWP L6

IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

Technical Data for IWP L6

M. Wt 472.58
Formula C25H20N4O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1427782-89-5
PubChem ID 71601111
Smiles O=C1C3=C(CCS3)N=C(SCC(NC4=NC=C(C5=CC=CC=C5)C=C4)=O)N1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IWP L6

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.26 100

Preparing Stock Solutions for IWP L6

The following data is based on the product molecular weight 472.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References for IWP L6

References are publications that support the biological activity of the product.

Wang et al (2013) The development of highly potent inhibitors for Porcupine. J.Med.Chem. 56 2700 PMID: 23477365

If you know of a relevant reference for IWP L6, please let us know.

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Keywords: IWP L6, IWP L6 supplier, IWPL6, MBOAT, membrane-bound, O-acyltransferases, inhibitors, inhibits, porcupine, porcn, Wnt, PORCN, 4992, Tocris Bioscience

Citations for IWP L6

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